Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2871166..2871637 | Replicon | chromosome |
| Accession | NZ_CP038374 | ||
| Organism | Escherichia coli O157:H7 strain F3113 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | E3160_RS13875 | Protein ID | WP_001303511.1 |
| Coordinates | 2871359..2871637 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | E3160_RS13870 | Protein ID | WP_001302048.1 |
| Coordinates | 2871166..2871357 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3160_RS13830 | 2866372..2866956 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
| E3160_RS13835 | 2867013..2867408 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
| E3160_RS13840 | 2867424..2868194 | - | 771 | WP_000450876.1 | DUF1627 domain-containing protein | - |
| E3160_RS13845 | 2868220..2868960 | - | 741 | WP_000788938.1 | ATP-binding protein | - |
| E3160_RS13850 | 2868967..2869929 | - | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| E3160_RS13855 | 2869952..2870377 | - | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| E3160_RS13860 | 2870374..2870676 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| E3160_RS13865 | 2870774..2871145 | + | 372 | WP_001169686.1 | hypothetical protein | - |
| E3160_RS13870 | 2871166..2871357 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| E3160_RS13875 | 2871359..2871637 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| E3160_RS13880 | 2871990..2872289 | + | 300 | WP_001240334.1 | hypothetical protein | - |
| E3160_RS13885 | 2872362..2872580 | + | 219 | WP_001171904.1 | hypothetical protein | - |
| E3160_RS13890 | 2872584..2872748 | - | 165 | WP_001331716.1 | hypothetical protein | - |
| E3160_RS13895 | 2873149..2873337 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| E3160_RS13900 | 2873334..2873525 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
| E3160_RS13905 | 2873618..2876089 | + | 2472 | WP_171880473.1 | 3'-5' exoribonuclease | - |
| E3160_RS13910 | 2876162..2876413 | + | 252 | WP_000005552.1 | excisionase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleA/espI | 2830736..2933014 | 102278 | |
| - | inside | Prophage | - | nleG7' / paa / espM1 / nleF / nleH2 / nleA/espI | 2777349..2933014 | 155665 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T122127 WP_001303511.1 NZ_CP038374:2871359-2871637 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T122127 NZ_CP038374:2871359-2871637 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT122127 WP_001302048.1 NZ_CP038374:2871166-2871357 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT122127 NZ_CP038374:2871166-2871357 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|