Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3683970..3684448 Replicon chromosome
Accession NZ_CP038372
Organism Escherichia coli O157:H7 strain F6294

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag E3161_RS19145 Protein ID WP_001303876.1
Coordinates 3684161..3684448 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag E3161_RS19140 Protein ID WP_000536233.1
Coordinates 3683970..3684161 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3161_RS19105 3679374..3680144 - 771 WP_000450992.1 DUF1627 domain-containing protein -
E3161_RS19110 3680166..3680912 - 747 WP_000788751.1 ATP-binding protein -
E3161_RS19115 3680919..3682010 - 1092 WP_001205823.1 hypothetical protein -
E3161_RS19120 3682089..3682544 + 456 WP_000273724.1 hypothetical protein -
E3161_RS19125 3682751..3683176 - 426 WP_000693855.1 Rha family transcriptional regulator -
E3161_RS19130 3683160..3683432 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
E3161_RS19135 3683541..3683942 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
E3161_RS19140 3683970..3684161 + 192 WP_000536233.1 hypothetical protein Antitoxin
E3161_RS19145 3684161..3684448 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E3161_RS19150 3684726..3684881 + 156 WP_000379575.1 DUF1391 family protein -
E3161_RS19155 3685023..3685412 + 390 WP_000394511.1 hypothetical protein -
E3161_RS19160 3685599..3685784 - 186 WP_001133046.1 hypothetical protein -
E3161_RS19165 3686358..3686546 + 189 WP_000413705.1 cell division inhibition protein DicB -
E3161_RS19170 3686543..3686734 + 192 WP_001098307.1 DUF1482 family protein -
E3161_RS19175 3686828..3689299 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T122100 WP_001303876.1 NZ_CP038372:3684161-3684448 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T122100 NZ_CP038372:3684161-3684448 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT122100 WP_000536233.1 NZ_CP038372:3683970-3684161 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT122100 NZ_CP038372:3683970-3684161 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References