Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3617355..3617833 Replicon chromosome
Accession NZ_CP038369
Organism Escherichia coli O157:H7 strain F6321

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag E3162_RS18745 Protein ID WP_001303876.1
Coordinates 3617546..3617833 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag E3162_RS18740 Protein ID WP_000536233.1
Coordinates 3617355..3617546 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3162_RS18705 3612759..3613529 - 771 WP_000450992.1 DUF1627 domain-containing protein -
E3162_RS18710 3613551..3614297 - 747 WP_000788751.1 ATP-binding protein -
E3162_RS18715 3614304..3615395 - 1092 WP_072143748.1 DNA-binding protein -
E3162_RS18720 3615474..3615929 + 456 WP_000273724.1 hypothetical protein -
E3162_RS18725 3616136..3616561 - 426 WP_000693855.1 Rha family transcriptional regulator -
E3162_RS18730 3616545..3616817 - 273 WP_032362955.1 helix-turn-helix domain-containing protein -
E3162_RS18735 3616926..3617327 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
E3162_RS18740 3617355..3617546 + 192 WP_000536233.1 hypothetical protein Antitoxin
E3162_RS18745 3617546..3617833 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E3162_RS18750 3618111..3618266 + 156 WP_000379575.1 DUF1391 family protein -
E3162_RS18755 3618408..3618797 + 390 WP_000394511.1 hypothetical protein -
E3162_RS18760 3618984..3619169 - 186 WP_001133046.1 hypothetical protein -
E3162_RS18765 3619743..3619931 + 189 WP_000413705.1 cell division inhibition protein DicB -
E3162_RS18770 3619928..3620119 + 192 WP_001098307.1 DUF1482 family protein -
E3162_RS18775 3620213..3622684 + 2472 WP_171879510.1 3'-5' exoribonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T122068 WP_001303876.1 NZ_CP038369:3617546-3617833 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T122068 NZ_CP038369:3617546-3617833 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT122068 WP_000536233.1 NZ_CP038369:3617355-3617546 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT122068 NZ_CP038369:3617355-3617546 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References