Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3629483..3629961 Replicon chromosome
Accession NZ_CP038351
Organism Escherichia coli O157:H7 strain F8798

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag E4U69_RS18865 Protein ID WP_001303876.1
Coordinates 3629674..3629961 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag E4U69_RS18860 Protein ID WP_000536233.1
Coordinates 3629483..3629674 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4U69_RS18825 3624887..3625657 - 771 WP_000450992.1 DUF1627 domain-containing protein -
E4U69_RS18830 3625679..3626425 - 747 WP_000788751.1 ATP-binding protein -
E4U69_RS18835 3626432..3627523 - 1092 WP_001205823.1 hypothetical protein -
E4U69_RS18840 3627602..3628057 + 456 WP_000273724.1 hypothetical protein -
E4U69_RS18845 3628264..3628689 - 426 WP_000693855.1 Rha family transcriptional regulator -
E4U69_RS18850 3628673..3628945 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
E4U69_RS18855 3629054..3629455 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
E4U69_RS18860 3629483..3629674 + 192 WP_000536233.1 hypothetical protein Antitoxin
E4U69_RS18865 3629674..3629961 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4U69_RS18870 3630239..3630394 + 156 WP_000379575.1 DUF1391 family protein -
E4U69_RS18875 3630536..3630925 + 390 WP_000394511.1 hypothetical protein -
E4U69_RS18880 3631112..3631297 - 186 WP_001133046.1 hypothetical protein -
E4U69_RS18885 3631871..3632059 + 189 WP_000413705.1 cell division inhibition protein DicB -
E4U69_RS18890 3632056..3632247 + 192 WP_001098307.1 DUF1482 family protein -
E4U69_RS18895 3632341..3634812 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T121821 WP_001303876.1 NZ_CP038351:3629674-3629961 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T121821 NZ_CP038351:3629674-3629961 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT121821 WP_000536233.1 NZ_CP038351:3629483-3629674 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT121821 NZ_CP038351:3629483-3629674 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References