Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | paaR-paaA-parE/- |
Location | 2507324..2507795 | Replicon | chromosome |
Accession | NZ_CP038344 | ||
Organism | Escherichia coli O157:H7 strain Gim1-1 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
Locus tag | E4U63_RS12440 | Protein ID | WP_001303511.1 |
Coordinates | 2507324..2507602 (-) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | paaA | Uniprot ID | Q8XAD5 |
Locus tag | E4U63_RS12445 | Protein ID | WP_001302048.1 |
Coordinates | 2507604..2507795 (-) | Length | 64 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E4U63_RS12400 | 2502330..2502514 | - | 185 | Protein_2422 | DUF3596 domain-containing protein | - |
E4U63_RS12405 | 2502549..2502800 | - | 252 | WP_000005552.1 | excisionase family protein | - |
E4U63_RS12410 | 2502873..2505344 | - | 2472 | WP_070080217.1 | exonuclease | - |
E4U63_RS12415 | 2505437..2505628 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
E4U63_RS12420 | 2505625..2505813 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
E4U63_RS12425 | 2506214..2506378 | + | 165 | WP_001331716.1 | hypothetical protein | - |
E4U63_RS12430 | 2506382..2506600 | - | 219 | WP_001171930.1 | hypothetical protein | - |
E4U63_RS12435 | 2506672..2506971 | - | 300 | WP_001240334.1 | hypothetical protein | - |
E4U63_RS12440 | 2507324..2507602 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
E4U63_RS12445 | 2507604..2507795 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
E4U63_RS12450 | 2507816..2508187 | - | 372 | WP_001169686.1 | hypothetical protein | - |
E4U63_RS12455 | 2508285..2508587 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
E4U63_RS12460 | 2508584..2509009 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
E4U63_RS12465 | 2509032..2509994 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
E4U63_RS12470 | 2510001..2510741 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
E4U63_RS12475 | 2510767..2511536 | + | 770 | Protein_2437 | DUF1627 domain-containing protein | - |
E4U63_RS12480 | 2511552..2511947 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
E4U63_RS12485 | 2512004..2512588 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | nleG7' | 2492444..2640552 | 148108 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T121703 WP_001303511.1 NZ_CP038344:c2507602-2507324 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T121703 NZ_CP038344:c2507602-2507324 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT121703 WP_001302048.1 NZ_CP038344:c2507795-2507604 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT121703 NZ_CP038344:c2507795-2507604 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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