Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3501361..3501839 Replicon chromosome
Accession NZ_CP038336
Organism Escherichia coli O157:H7 strain LSU61

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag E3165_RS17870 Protein ID WP_001303876.1
Coordinates 3501552..3501839 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag E3165_RS17865 Protein ID WP_000536233.1
Coordinates 3501361..3501552 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3165_RS17830 3496765..3497535 - 771 WP_000450992.1 DUF1627 domain-containing protein -
E3165_RS17835 3497557..3498303 - 747 WP_000788751.1 ATP-binding protein -
E3165_RS17840 3498310..3499401 - 1092 WP_001205823.1 hypothetical protein -
E3165_RS17845 3499480..3499935 + 456 WP_000273724.1 hypothetical protein -
E3165_RS17850 3500142..3500567 - 426 WP_000693855.1 Rha family transcriptional regulator -
E3165_RS17855 3500551..3500823 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
E3165_RS17860 3500932..3501333 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
E3165_RS17865 3501361..3501552 + 192 WP_000536233.1 hypothetical protein Antitoxin
E3165_RS17870 3501552..3501839 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E3165_RS17875 3502116..3502271 + 156 WP_000379575.1 DUF1391 family protein -
E3165_RS17880 3502413..3502802 + 390 WP_000394511.1 hypothetical protein -
E3165_RS17885 3502989..3503174 - 186 WP_001133046.1 hypothetical protein -
E3165_RS17890 3503748..3503936 + 189 WP_000413705.1 cell division inhibition protein DicB -
E3165_RS17895 3503933..3504124 + 192 WP_001098307.1 DUF1482 family protein -
E3165_RS17900 3504218..3506689 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T121600 WP_001303876.1 NZ_CP038336:3501552-3501839 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T121600 NZ_CP038336:3501552-3501839 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT121600 WP_000536233.1 NZ_CP038336:3501361-3501552 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT121600 NZ_CP038336:3501361-3501552 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References