Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | paaR-paaA-parE/- |
Location | 2545665..2546136 | Replicon | chromosome |
Accession | NZ_CP038336 | ||
Organism | Escherichia coli O157:H7 strain LSU61 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
Locus tag | E3165_RS12540 | Protein ID | WP_001303511.1 |
Coordinates | 2545665..2545943 (-) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | paaA | Uniprot ID | Q8XAD5 |
Locus tag | E3165_RS12545 | Protein ID | WP_001302048.1 |
Coordinates | 2545945..2546136 (-) | Length | 64 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E3165_RS12510 | 2541259..2543685 | - | 2427 | Protein_2449 | 3'-5' exoribonuclease | - |
E3165_RS12515 | 2543778..2543969 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
E3165_RS12520 | 2543966..2544154 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
E3165_RS12525 | 2544555..2544719 | + | 165 | WP_001331716.1 | hypothetical protein | - |
E3165_RS12530 | 2544723..2544941 | - | 219 | WP_001171930.1 | hypothetical protein | - |
E3165_RS12535 | 2545013..2545312 | - | 300 | WP_001240334.1 | hypothetical protein | - |
E3165_RS12540 | 2545665..2545943 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
E3165_RS12545 | 2545945..2546136 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
E3165_RS12550 | 2546157..2546528 | - | 372 | WP_001169686.1 | hypothetical protein | - |
E3165_RS12555 | 2546626..2546928 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
E3165_RS12560 | 2546925..2547350 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
E3165_RS12565 | 2547373..2548335 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
E3165_RS12570 | 2548342..2549082 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
E3165_RS12575 | 2549108..2549878 | + | 771 | WP_000450876.1 | DUF1627 domain-containing protein | - |
E3165_RS12580 | 2549894..2550289 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
E3165_RS12585 | 2550346..2550870 | + | 525 | WP_171877379.1 | DUF551 domain-containing protein | - |
E3165_RS12590 | 2550877..2550930 | + | 54 | Protein_2465 | DUF551 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | nleA/espI / nleH2 / nleF / espM1 / paa / nleG7' / nleC | 2530821..2698192 | 167371 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T121593 WP_001303511.1 NZ_CP038336:c2545943-2545665 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T121593 NZ_CP038336:c2545943-2545665 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT121593 WP_001302048.1 NZ_CP038336:c2546136-2545945 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT121593 NZ_CP038336:c2546136-2545945 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 5CZF | |
PDB | 5CW7 | |
PDB | 5CZE |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CTP0 |