Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3610660..3611138 Replicon chromosome
Accession NZ_CP038309
Organism Escherichia coli O157:H7 strain Show KS 470-1

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag E4U84_RS18705 Protein ID WP_001303876.1
Coordinates 3610851..3611138 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag E4U84_RS18700 Protein ID WP_000536233.1
Coordinates 3610660..3610851 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4U84_RS18665 3606064..3606834 - 771 WP_000450992.1 DUF1627 domain-containing protein -
E4U84_RS18670 3606856..3607602 - 747 WP_000788751.1 ATP-binding protein -
E4U84_RS18675 3607609..3608700 - 1092 WP_001205823.1 hypothetical protein -
E4U84_RS18680 3608779..3609234 + 456 WP_000273724.1 hypothetical protein -
E4U84_RS18685 3609441..3609866 - 426 WP_000693855.1 Rha family transcriptional regulator -
E4U84_RS18690 3609850..3610122 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
E4U84_RS18695 3610231..3610632 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
E4U84_RS18700 3610660..3610851 + 192 WP_000536233.1 hypothetical protein Antitoxin
E4U84_RS18705 3610851..3611138 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4U84_RS18710 3611416..3611571 + 156 WP_000379575.1 DUF1391 family protein -
E4U84_RS18715 3611713..3612102 + 390 WP_000394511.1 hypothetical protein -
E4U84_RS18720 3612289..3612474 - 186 WP_001133046.1 hypothetical protein -
E4U84_RS18725 3613048..3613236 + 189 WP_000413705.1 cell division inhibition protein DicB -
E4U84_RS18730 3613233..3613424 + 192 WP_001098307.1 DUF1482 family protein -
E4U84_RS18735 3613518..3615989 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T121318 WP_001303876.1 NZ_CP038309:3610851-3611138 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T121318 NZ_CP038309:3610851-3611138 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT121318 WP_000536233.1 NZ_CP038309:3610660-3610851 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT121318 NZ_CP038309:3610660-3610851 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References