Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3642026..3642504 Replicon chromosome
Accession NZ_CP038290
Organism Escherichia coli O157:H7 strain TX 265-1

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag E4U08_RS18895 Protein ID WP_001303876.1
Coordinates 3642217..3642504 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag E4U08_RS18890 Protein ID WP_000536233.1
Coordinates 3642026..3642217 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4U08_RS18855 3637430..3638200 - 771 WP_000450992.1 DUF1627 domain-containing protein -
E4U08_RS18860 3638222..3638968 - 747 WP_000788751.1 ATP-binding protein -
E4U08_RS18865 3638975..3640066 - 1092 WP_001205823.1 hypothetical protein -
E4U08_RS18870 3640145..3640600 + 456 WP_000273724.1 hypothetical protein -
E4U08_RS18875 3640807..3641232 - 426 WP_000693855.1 Rha family transcriptional regulator -
E4U08_RS18880 3641216..3641488 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
E4U08_RS18885 3641597..3641998 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
E4U08_RS18890 3642026..3642217 + 192 WP_000536233.1 hypothetical protein Antitoxin
E4U08_RS18895 3642217..3642504 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4U08_RS18900 3642782..3642937 + 156 WP_000379575.1 DUF1391 family protein -
E4U08_RS18905 3643079..3643468 + 390 WP_000394511.1 hypothetical protein -
E4U08_RS18910 3643655..3643840 - 186 WP_001133046.1 hypothetical protein -
E4U08_RS18915 3644414..3644602 + 189 WP_000413705.1 cell division inhibition protein DicB -
E4U08_RS18920 3644599..3644790 + 192 WP_001098307.1 DUF1482 family protein -
E4U08_RS18925 3644884..3647355 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T121099 WP_001303876.1 NZ_CP038290:3642217-3642504 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T121099 NZ_CP038290:3642217-3642504 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT121099 WP_000536233.1 NZ_CP038290:3642026-3642217 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT121099 NZ_CP038290:3642026-3642217 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References