Detailed information of TA system TA120951

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 5616712..5617625
• Replicon: chromosome
• Accession: NZ_CP038281
• Organism: Raoultella ornithinolytica strain WLK218

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: E4K08_RS30490
• Protein ID: WP_004862779.1
• Coordinates: 5617152..5617625 (+)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: E4K08_RS30485
• Protein ID: WP_032716402.1
• Coordinates: 5616712..5617155 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4K08_RS30450	5611945..5612421	+	477	WP_071887178.1	acid resistance repetitive basic protein Asr	-
E4K08_RS30470	5613356..5614579	-	1224	WP_004862767.1	zinc metallochaperone GTPase ZigA	-
E4K08_RS30475	5614776..5615558	-	783	WP_069475890.1	DUF3750 domain-containing protein	-
E4K08_RS30480	5615956..5616522	+	567	WP_015584190.1	DJ-1/PfpI family protein	-
E4K08_RS30485	5616712..5617155	+	444	WP_032716402.1	DUF2384 domain-containing protein	Antitoxin
E4K08_RS30490	5617152..5617625	+	474	WP_004862779.1	RES domain-containing protein	Toxin
E4K08_RS30495	5617706..5618485	-	780	WP_137056651.1	SDR family oxidoreductase	-
E4K08_RS30500	5618478..5618795	-	318	WP_004862785.1	nuclear transport factor 2 family protein	-
E4K08_RS30505	5618898..5619803	+	906	WP_044349852.1	LysR family transcriptional regulator	-
E4K08_RS30510	5619831..5620736	-	906	WP_032716408.1	transcriptional regulator GcvA	-
E4K08_RS30515	5620978..5621586	+	609	WP_044349854.1	glutathione S-transferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (95-144)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17523.84 Da
• Isoelectric Point: 5.0735

>T120951 WP_004862779.1 NZ_CP038281:5617152-5617625 [Raoultella ornithinolytica]
MIFYRLVTGRYASEAWTGSGANQYGGRWNHQGHPAVYVSTSIALASLEILVHVKNEAILNQYQLYSIEIPNSEVESLDKQ
WLPDNWQENPMPVSTMDLGTGWLQSGSGLALMLPSCIIPYENNAILNPLHPAFSEALASVRQYPFTFDPRLARSTPL

Nucleotide

• Length: 474 bp

>T120951 NZ_CP038281:5617152-5617625 [Raoultella ornithinolytica]
ATGATTTTCTATCGTCTGGTTACCGGCCGTTACGCCAGCGAAGCCTGGACGGGAAGCGGGGCCAACCAGTACGGCGGGCG
CTGGAATCACCAGGGACACCCGGCGGTCTATGTGTCCACTTCCATTGCCCTGGCGTCACTGGAGATCCTGGTTCACGTCA
AAAATGAGGCAATCCTCAACCAGTATCAGCTGTATAGTATCGAGATACCGAACAGCGAAGTGGAATCCCTCGATAAACAG
TGGTTACCGGATAACTGGCAAGAAAATCCGATGCCCGTTTCCACAATGGATCTGGGCACCGGCTGGCTACAGTCGGGCAG
CGGTCTGGCGCTGATGCTTCCCTCCTGCATTATTCCCTATGAAAACAACGCCATTTTAAACCCGCTGCATCCCGCGTTCA
GCGAGGCCCTGGCCTCCGTGCGTCAGTATCCCTTTACCTTTGATCCCCGCCTCGCACGCTCCACGCCCCTTTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16176.42 Da
• Isoelectric Point: 4.9405

>AT120951 WP_032716402.1 NZ_CP038281:5616712-5617155 [Raoultella ornithinolytica]
MKTWVPAEQPADNALWRYAGLPANRGMQLIELLSMGLPVSVLDNIHEWTEMSKTDILRITGINERNVARRKSAGGTLTPG
ESERVARFVRVLDTAVDYFGSKQDAYDWLQSPVRGLGNVAPIDLIATESGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT120951 NZ_CP038281:5616712-5617155 [Raoultella ornithinolytica]
ATGAAAACCTGGGTTCCTGCAGAGCAACCTGCCGATAATGCGCTGTGGCGCTATGCCGGGCTACCGGCGAATCGGGGTAT
GCAGTTGATTGAGCTGCTGAGTATGGGATTACCGGTCAGCGTTCTGGATAATATTCATGAGTGGACGGAAATGTCGAAAA
CCGACATTCTGCGCATCACCGGGATTAATGAGCGCAACGTTGCCCGGCGCAAGAGCGCGGGCGGCACGTTGACGCCAGGC
GAAAGCGAACGTGTGGCGCGTTTTGTCAGGGTCCTGGATACCGCCGTCGACTATTTTGGCAGCAAGCAGGATGCCTACGA
CTGGCTGCAGTCGCCGGTCAGAGGACTGGGCAATGTCGCCCCCATCGATCTGATTGCTACCGAGAGCGGCGCGCTGGAAG
TAACAGACCTGATTGGTCGCCTGGAACACGGCGTCTTTGCATGA