Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/ElaA-DUF1778 |
Location | 10579..11318 | Replicon | plasmid pWLK-107717 |
Accession | NZ_CP038276 | ||
Organism | Raoultella ornithinolytica strain WLK218 |
Toxin (Protein)
Gene name | tacT | Uniprot ID | - |
Locus tag | E4K08_RS00725 | Protein ID | WP_076752153.1 |
Coordinates | 10579..11064 (-) | Length | 162 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | A0A5E1AWX8 |
Locus tag | E4K08_RS00730 | Protein ID | WP_012540086.1 |
Coordinates | 11052..11318 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E4K08_RS00685 | 5769..5999 | - | 231 | WP_076752138.1 | hypothetical protein | - |
E4K08_RS00690 | 6088..6435 | - | 348 | WP_076752140.1 | hypothetical protein | - |
E4K08_RS00695 | 6538..6810 | - | 273 | WP_137055850.1 | hypothetical protein | - |
E4K08_RS00700 | 7700..8116 | - | 417 | WP_076752145.1 | helix-turn-helix domain-containing protein | - |
E4K08_RS00705 | 8113..8424 | - | 312 | WP_076752146.1 | type II toxin-antitoxin system HigB family toxin | - |
E4K08_RS00710 | 8574..8786 | - | 213 | WP_076752148.1 | hypothetical protein | - |
E4K08_RS00715 | 8894..9220 | - | 327 | WP_076752150.1 | hypothetical protein | - |
E4K08_RS00720 | 10079..10237 | - | 159 | WP_076752152.1 | type I toxin-antitoxin system Hok family toxin | - |
E4K08_RS00725 | 10579..11064 | - | 486 | WP_076752153.1 | GNAT family N-acetyltransferase | Toxin |
E4K08_RS00730 | 11052..11318 | - | 267 | WP_012540086.1 | DUF1778 domain-containing protein | Antitoxin |
E4K08_RS00735 | 11619..11942 | + | 324 | WP_013087171.1 | metalloregulator ArsR/SmtB family transcription factor | - |
E4K08_RS00740 | 11944..12657 | + | 714 | WP_013087170.1 | arsenical resistance protein ArsH | - |
E4K08_RS00745 | 12666..13211 | + | 546 | WP_047365773.1 | sigma-70 family RNA polymerase sigma factor | - |
E4K08_RS00750 | 13287..13649 | + | 363 | WP_013087168.1 | arsenic metallochaperone ArsD family protein | - |
E4K08_RS00755 | 13676..15427 | + | 1752 | WP_175406650.1 | arsenical pump-driving ATPase | - |
E4K08_RS00760 | 15552..16088 | + | 537 | WP_013087166.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..107717 | 107717 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17838.68 Da Isoelectric Point: 10.0748
>T120933 WP_076752153.1 NZ_CP038276:c11064-10579 [Raoultella ornithinolytica]
VGRVTVPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSRTQQRTLFLKLP
Q
VGRVTVPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSRTQQRTLFLKLP
Q
Download Length: 486 bp
>T120933 NZ_CP038276:c11064-10579 [Raoultella ornithinolytica]
GTGGGACGTGTAACAGTACCAGAACCTTTATCCAGCTTTCATCAGGTGGCGGAATTCGTTTGCGGTGAAACTGTTCTGGA
TGACTGGTTAAAGCAGAAAGGCCTCAAAAACCAGGCTCTCGGATCGGCCAGAACGTTTGTAGTGTGTAAAAAAGACACGA
AACAAGTAGCCGGTTTTTACTCTCTGGCCACCGGGAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCCGATCCCATCCCTGTTATTATACTTGCCCGTCTTGCTGTCGATCTCTCTTTCCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTCACCG
AAGAAGCTAAAAATTTCTACATTCACCATGGTTTCAAACCATCACGAACTCAGCAACGGACATTATTTCTTAAACTCCCT
CAATAG
GTGGGACGTGTAACAGTACCAGAACCTTTATCCAGCTTTCATCAGGTGGCGGAATTCGTTTGCGGTGAAACTGTTCTGGA
TGACTGGTTAAAGCAGAAAGGCCTCAAAAACCAGGCTCTCGGATCGGCCAGAACGTTTGTAGTGTGTAAAAAAGACACGA
AACAAGTAGCCGGTTTTTACTCTCTGGCCACCGGGAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCCGATCCCATCCCTGTTATTATACTTGCCCGTCTTGCTGTCGATCTCTCTTTCCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTCACCG
AAGAAGCTAAAAATTTCTACATTCACCATGGTTTCAAACCATCACGAACTCAGCAACGGACATTATTTCTTAAACTCCCT
CAATAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 10076.47 Da Isoelectric Point: 4.3721
>AT120933 WP_012540086.1 NZ_CP038276:c11318-11052 [Raoultella ornithinolytica]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV
Download Length: 267 bp
>AT120933 NZ_CP038276:c11318-11052 [Raoultella ornithinolytica]
ATGAAATCAGATGTTCAACTTAATCTTAGAGCAAAGGAATCACAGCGGGCGCTCATTGATGCTGCTGCGGAAATTCTTCA
CAAATCACGAACAGACTTCATCCTGGAAATGGCCTGTCAGGCCGCTGAGAACGTGATCCTCGATCGCCGGGTCTTTAATT
TTAACGATGAACAATATGCCGAATTCATCGACATGCTTGATGCCCCTGTTGCAGATGATCCTGCCATAGATAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA
ATGAAATCAGATGTTCAACTTAATCTTAGAGCAAAGGAATCACAGCGGGCGCTCATTGATGCTGCTGCGGAAATTCTTCA
CAAATCACGAACAGACTTCATCCTGGAAATGGCCTGTCAGGCCGCTGAGAACGTGATCCTCGATCGCCGGGTCTTTAATT
TTAACGATGAACAATATGCCGAATTCATCGACATGCTTGATGCCCCTGTTGCAGATGATCCTGCCATAGATAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|