Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 15724..16258 Replicon plasmid unnamed1
Accession NZ_CP038274
Organism Legionella israelensis strain Bercovier 4

Toxin (Protein)


Gene name relE Uniprot ID A0A0W0VH57
Locus tag E4T55_RS14945 Protein ID WP_058502381.1
Coordinates 15724..16005 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0W0VH73
Locus tag E4T55_RS14950 Protein ID WP_058502380.1
Coordinates 15992..16258 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4T55_RS14920 11858..12538 + 681 WP_115325410.1 class I SAM-dependent methyltransferase -
E4T55_RS14925 12531..12863 + 333 WP_058502213.1 hypothetical protein -
E4T55_RS14930 12923..13027 + 105 Protein_15 transposase -
E4T55_RS14935 13091..13792 + 702 WP_058502214.1 IS6 family transposase -
E4T55_RS14940 14151..15259 - 1109 Protein_17 IS3 family transposase -
E4T55_RS14945 15724..16005 - 282 WP_058502381.1 type II toxin-antitoxin system YafQ family toxin Toxin
E4T55_RS14950 15992..16258 - 267 WP_058502380.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
E4T55_RS14955 16473..16907 - 435 WP_058502412.1 type II toxin-antitoxin system YhaV family toxin -
E4T55_RS14960 16964..17293 - 330 WP_058502379.1 type II toxin-antitoxin system PrlF family antitoxin -
E4T55_RS14965 17489..17764 + 276 WP_058502378.1 DUF1778 domain-containing protein -
E4T55_RS14970 17764..18276 + 513 WP_058502377.1 GNAT family N-acetyltransferase -
E4T55_RS14975 18437..19063 + 627 WP_058502376.1 recombinase family protein -
E4T55_RS14980 19324..19530 + 207 WP_058502411.1 cold-shock protein -
E4T55_RS14985 19593..19667 + 75 Protein_26 acetoacetyl-CoA reductase -
E4T55_RS14990 19831..21111 - 1281 WP_058501406.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..47309 47309


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-82)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11063.78 Da        Isoelectric Point: 9.3784

>T120931 WP_058502381.1 NZ_CP038274:c16005-15724 [Legionella israelensis]
MRTIERSTKFKKDYKRELKGRYRDILESELKTILVPLINDEALDIRYRDHDLSGNWAGYRECHIKPDLLLIYRKLDGDIL
KLARLGSHSELFS

Download         Length: 282 bp

>T120931 NZ_CP038274:c16005-15724 [Legionella israelensis]
ATGCGGACGATTGAACGCTCAACGAAATTTAAAAAAGATTACAAGCGAGAATTAAAAGGCAGGTATCGAGATATCCTTGA
ATCAGAATTAAAGACGATTCTGGTTCCGCTAATCAATGATGAAGCTTTGGACATTCGCTATCGTGACCACGATTTAAGCG
GTAACTGGGCAGGCTATCGAGAATGCCATATCAAGCCTGATTTGCTTTTGATTTACCGTAAGCTGGATGGTGATATCCTA
AAACTTGCCAGGCTTGGCTCTCACAGTGAGCTTTTTAGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9873.30 Da        Isoelectric Point: 4.6968

>AT120931 WP_058502380.1 NZ_CP038274:c16258-15992 [Legionella israelensis]
MANVDTYVRARIDSETKMRAADALEAMGLSVSDAIRLLMLRIADEKRMPFEVRVPNKATRDAIRELEEGKGKKFSSIDAL
MDDLNADD

Download         Length: 267 bp

>AT120931 NZ_CP038274:c16258-15992 [Legionella israelensis]
ATGGCTAATGTAGACACCTATGTACGTGCCAGAATCGATTCGGAAACCAAAATGCGAGCTGCCGATGCATTAGAGGCGAT
GGGGCTATCGGTATCCGATGCCATTCGCCTGTTGATGTTGCGCATTGCTGATGAAAAGCGTATGCCTTTTGAAGTCAGGG
TTCCTAATAAGGCGACCAGGGATGCCATACGTGAACTTGAAGAAGGCAAGGGTAAAAAATTCAGCAGCATTGATGCTTTG
ATGGATGATCTGAATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0VH57

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0VH73

References