Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1568713..1570253 Replicon chromosome
Accession NZ_CP038273
Organism Legionella israelensis strain Bercovier 4

Toxin (Protein)


Gene name hipA Uniprot ID A0A0W0V1I0
Locus tag E4T55_RS06960 Protein ID WP_058503010.1
Coordinates 1568713..1570020 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0W0V2M6
Locus tag E4T55_RS06965 Protein ID WP_058503011.1
Coordinates 1570014..1570253 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4T55_RS06940 1564905..1565255 + 351 WP_058503006.1 hypothetical protein -
E4T55_RS06945 1565480..1566514 - 1035 WP_058503007.1 IS481 family transposase -
E4T55_RS06950 1566686..1567093 - 408 Protein_1367 IS4 family transposase -
E4T55_RS06955 1567422..1568672 + 1251 WP_058503009.1 integrase family protein -
E4T55_RS06960 1568713..1570020 - 1308 WP_058503010.1 type II toxin-antitoxin system HipA family toxin Toxin
E4T55_RS06965 1570014..1570253 - 240 WP_058503011.1 helix-turn-helix domain-containing protein Antitoxin
E4T55_RS06970 1570808..1571080 + 273 WP_058503012.1 helix-turn-helix domain-containing protein -
E4T55_RS06975 1571169..1572914 + 1746 Protein_1372 DUF927 domain-containing protein -
E4T55_RS06980 1573019..1573828 - 810 WP_058503086.1 integrase -
E4T55_RS06985 1574290..1574484 + 195 WP_058503013.1 hypothetical protein -
E4T55_RS06990 1574582..1575007 + 426 WP_058503014.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 49754.15 Da        Isoelectric Point: 7.7186

>T120928 WP_058503010.1 NZ_CP038273:c1570020-1568713 [Legionella israelensis]
MVMRKLYILMNHELVGELTQDNAGGLSFSYVADWLSKPYSRPVSLSLPLITQKFSGEVVYNFFDNLLPDNPQIRARIQAR
FQASSSRPFDLLALIGSDCVGAIQIVEEIPERQEKKIECKIVSEAEIAHTLRSYQISPLGMDKEDDEFRISIAGAQEKTA
FLYYQNKWHKPFGPTPTTHIFKLPIGYLSHQGIDLSESCENEHLCLLLASKFGLDVAKSKILQFEDVKVLVVERFDRKWS
RDNRYILRLPQEDLCQSLGYSPNLKYQSDGGPGIKEIMQLLNGSQQPQKDRDEFFRAQVVYWCLGAIDAHAKNFSISIQA
QGGYQLTPLYDIISAYPLVEQKQLQFKKLKMAMALYGKNSHYKIDGIQKRHFIETAKYVQYSKIKAAQIFEQVIDRIESA
IDEVSTELPNHFPERIADPIFKGMRAFKARMTSTS

Download         Length: 1308 bp

>T120928 NZ_CP038273:c1570020-1568713 [Legionella israelensis]
ATGGTAATGCGTAAATTATACATATTGATGAACCATGAGCTCGTTGGGGAGCTTACCCAGGATAATGCAGGAGGTTTGAG
TTTTTCCTACGTTGCTGACTGGCTTTCCAAGCCGTATTCACGGCCGGTTTCTTTATCGCTACCATTAATAACGCAAAAGT
TCTCAGGTGAAGTTGTTTATAACTTTTTTGATAACTTACTCCCTGATAATCCGCAGATAAGAGCCAGAATTCAAGCTCGT
TTTCAGGCAAGTTCATCACGACCGTTTGATTTATTAGCTTTAATTGGTAGTGATTGTGTTGGTGCAATACAAATCGTTGA
AGAAATTCCCGAGAGACAAGAAAAAAAAATTGAGTGTAAAATTGTTAGTGAGGCCGAGATAGCTCATACTTTACGTTCCT
ATCAGATCTCGCCACTGGGAATGGATAAAGAAGATGATGAATTTAGAATATCGATAGCAGGCGCTCAGGAAAAAACCGCT
TTTCTATATTATCAAAACAAATGGCATAAACCATTTGGACCTACACCAACAACTCATATATTCAAACTACCTATTGGGTA
TTTATCTCATCAAGGGATTGATTTAAGTGAGAGTTGTGAAAATGAACATCTCTGTTTACTACTGGCGAGCAAATTTGGTT
TAGATGTTGCGAAATCTAAAATCTTACAATTCGAAGATGTAAAAGTATTGGTTGTCGAAAGATTTGATAGAAAATGGAGT
CGAGATAATCGGTATATTCTCAGATTGCCGCAGGAAGATCTTTGCCAATCATTGGGATACTCACCAAATTTAAAATATCA
GTCTGATGGTGGGCCGGGTATTAAAGAAATTATGCAGCTACTTAATGGCTCACAGCAGCCTCAAAAAGACAGAGATGAAT
TTTTCAGGGCACAGGTTGTTTACTGGTGCCTTGGTGCTATTGATGCGCATGCCAAAAATTTCAGTATAAGCATACAAGCG
CAAGGCGGTTACCAGCTAACCCCATTATACGACATCATTTCAGCCTACCCTTTAGTCGAACAAAAACAGTTACAGTTTAA
GAAATTGAAAATGGCAATGGCGTTATATGGTAAAAATAGTCATTATAAGATTGACGGTATTCAAAAAAGACACTTTATTG
AAACGGCAAAATACGTTCAATATTCTAAAATTAAAGCAGCTCAGATTTTTGAACAAGTGATTGACCGTATCGAATCTGCT
ATTGATGAGGTCTCAACAGAGTTACCAAACCACTTCCCAGAAAGGATTGCAGATCCAATCTTCAAAGGGATGAGAGCTTT
TAAGGCGCGAATGACGTCCACTTCATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9023.30 Da        Isoelectric Point: 4.7672

>AT120928 WP_058503011.1 NZ_CP038273:c1570253-1570014 [Legionella israelensis]
MIISSAKDLALYLNDKRKQLKMSQSEVADLVGLKQDTISKFENSPDNSRIDTLFRILSALNLNMSLVEKEQAAHEEIEW

Download         Length: 240 bp

>AT120928 NZ_CP038273:c1570253-1570014 [Legionella israelensis]
ATGATCATCAGCTCAGCAAAAGATTTAGCATTGTATTTGAATGACAAGCGTAAGCAACTCAAAATGAGTCAATCTGAAGT
TGCCGATTTAGTCGGTTTAAAACAGGATACCATATCAAAGTTTGAAAATAGCCCTGATAATAGCCGAATTGATACTTTAT
TTAGAATATTGTCTGCCCTTAATTTAAATATGAGTCTTGTTGAAAAAGAGCAAGCTGCTCATGAAGAGATAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0V1I0

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0V2M6

References