Detailed information of TA system TA120926

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1793286..1793859
• Replicon: chromosome
• Accession: NZ_CP038271
• Organism: Legionella geestiana strain 1308

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0W0TP77
• Locus tag: E4T54_RS07995
• Protein ID: WP_028387426.1
• Coordinates: 1793286..1793570 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: E4T54_RS08000
• Protein ID: WP_028387427.1
• Coordinates: 1793563..1793859 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4T54_RS07985	1790923..1792056	+	1134	WP_135100403.1	hypothetical protein	-
E4T54_RS07990	1792239..1793111	+	873	WP_135100404.1	hypothetical protein	-
E4T54_RS07995	1793286..1793570	-	285	WP_028387426.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
E4T54_RS08000	1793563..1793859	-	297	WP_028387427.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E4T54_RS08005	1794136..1794815	-	680	Protein_1565	Tn3 family transposase	-
E4T54_RS08010	1794981..1795163	-	183	Protein_1566	Tn3 family transposase	-
E4T54_RS08015	1795225..1795479	+	255	WP_058387133.1	hypothetical protein	-
E4T54_RS08020	1795523..1797844	-	2322	WP_162150901.1	ankyrin repeat domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1794136..1794666	530

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-58)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10702.22 Da
• Isoelectric Point: 4.4843

>T120926 WP_028387426.1 NZ_CP038271:c1793570-1793286 [Legionella geestiana]
VPELEWLALARADLLEIVDYISDDNPDAAQRVKDDIEAKVAKLPDFPKIGRPGRIEGTRELVVWANYIIVYQEDAFAIQI
LRVLHAAQQWPPSH

Nucleotide

• Length: 285 bp

>T120926 NZ_CP038271:c1793570-1793286 [Legionella geestiana]
GTGCCTGAATTGGAATGGTTAGCTTTAGCTCGTGCCGATCTTTTAGAGATTGTAGACTATATCTCAGATGACAACCCAGA
TGCAGCCCAGCGCGTAAAGGATGATATTGAGGCGAAAGTCGCAAAACTACCAGATTTTCCTAAAATTGGCCGTCCTGGTC
GAATAGAAGGAACCAGAGAATTGGTCGTCTGGGCGAATTATATTATCGTGTATCAAGAAGATGCTTTTGCCATTCAAATA
CTTCGTGTGTTGCATGCGGCACAACAGTGGCCACCATCCCATTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10886.56 Da
• Isoelectric Point: 10.5548

>AT120926 WP_028387427.1 NZ_CP038271:c1793859-1793563 [Legionella geestiana]
IMAHTSMLHVRVDDKLKADAAKNLASFGLTVSDAVRILLTRITKEGGLPVGLTADPEAHDAWFRNKVKEALADTRPTVSH
KQVMDEAQTLIDRKRRRA

Nucleotide

• Length: 297 bp

>AT120926 NZ_CP038271:c1793859-1793563 [Legionella geestiana]
ATCATGGCTCATACTTCAATGCTGCATGTTCGCGTAGACGATAAGTTGAAGGCTGATGCAGCGAAAAATCTTGCAAGTTT
TGGTTTGACTGTATCTGATGCCGTCCGTATTTTATTGACTCGCATAACCAAAGAAGGCGGCTTGCCCGTTGGATTAACGG
CTGATCCAGAAGCACATGATGCTTGGTTCCGTAACAAGGTGAAAGAAGCTCTCGCTGACACGCGACCCACTGTATCTCAT
AAACAGGTAATGGACGAGGCACAAACATTAATTGATCGGAAGCGTCGCCGTGCCTGA

Structures

Toxin

• AlphaFold DB: A0A0W0TP77