Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2129702..2130216 Replicon chromosome
Accession NZ_CP038270
Organism Staphylococcus aureus strain O408 isolate B115

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag SaO408_RS10910 Protein ID WP_000603099.1
Coordinates 2129702..2129911 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag SaO408_RS10915 Protein ID WP_000138933.1
Coordinates 2129923..2130216 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO408_RS10890 2125210..2126568 - 1359 WP_000611458.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SaO408_RS10895 2126583..2127653 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
SaO408_RS10900 2127971..2129173 + 1203 WP_001109939.1 rod shape-determining protein RodA -
SaO408_RS10905 2129437..2129574 - 138 WP_000828354.1 hypothetical protein -
SaO408_RS10910 2129702..2129911 - 210 WP_000603099.1 heavy-metal-associated domain-containing protein Toxin
SaO408_RS10915 2129923..2130216 - 294 WP_000138933.1 copper-sensing transcriptional repressor CsoR Antitoxin
SaO408_RS10920 2130382..2131866 + 1485 WP_000571551.1 cardiolipin synthase -
SaO408_RS10925 2131894..2132556 + 663 WP_001187618.1 HD domain-containing protein -
SaO408_RS10940 2133307..2134179 - 873 WP_000725802.1 membrane protein insertase YidC -
SaO408_RS10945 2134265..2134906 - 642 WP_000483158.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7819.79 Da        Isoelectric Point: 3.9389

>T120921 WP_000603099.1 NZ_CP038270:c2129911-2129702 [Staphylococcus aureus]
MILQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T120921 NZ_CP038270:c2129911-2129702 [Staphylococcus aureus]
ATGATACTTCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.81 Da        Isoelectric Point: 6.7122

>AT120921 WP_000138933.1 NZ_CP038270:c2130216-2129923 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNKGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT120921 NZ_CP038270:c2130216-2129923 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATAAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References