Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 883629..884106 Replicon chromosome
Accession NZ_CP038270
Organism Staphylococcus aureus strain O408 isolate B115

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SaO408_RS04440 Protein ID WP_000052076.1
Coordinates 883629..883817 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SaO408_RS04445 Protein ID WP_001059690.1
Coordinates 883846..884106 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO408_RS04410 879673..880143 + 471 WP_000824470.1 hypothetical protein -
SaO408_RS04415 880484..881170 + 687 WP_001804081.1 thermonuclease family protein -
SaO408_RS04420 881522..881722 + 201 WP_001059082.1 cold-shock protein -
SaO408_RS04425 882220..882438 - 219 WP_000005880.1 hypothetical protein -
SaO408_RS04430 882500..882784 - 285 WP_001004401.1 hypothetical protein -
SaO408_RS04435 882872..883441 - 570 WP_001106650.1 hypothetical protein -
SaO408_RS04440 883629..883817 - 189 WP_000052076.1 hypothetical protein Toxin
SaO408_RS04445 883846..884106 - 261 WP_001059690.1 hypothetical protein Antitoxin
SaO408_RS04450 884447..884650 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SaO408_RS04455 884647..884883 - 237 WP_000368687.1 hypothetical protein -
SaO408_RS04460 885108..885689 + 582 WP_001140691.1 phosphoglycerate mutase family protein -
SaO408_RS04465 885762..886379 - 618 WP_000255563.1 LysE/ArgO family amino acid transporter -
SaO408_RS04470 886535..887029 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
SaO408_RS04475 887428..887850 - 423 WP_000974454.1 organic hydroperoxide resistance protein -
SaO408_RS04480 887998..888714 + 717 WP_000150031.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-99)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T120916 WP_000052076.1 NZ_CP038270:c883817-883629 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T120916 NZ_CP038270:c883817-883629 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTTTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTACTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT120916 WP_001059690.1 NZ_CP038270:c884106-883846 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT120916 NZ_CP038270:c884106-883846 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATAAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References