120907

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2020778..2021292 Replicon chromosome
Accession NZ_CP038269
Organism Staphylococcus aureus strain O331 isolate B114

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag SaO331_RS10210 Protein ID WP_000581792.1
Coordinates 2020778..2020987 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag SaO331_RS10215 Protein ID WP_000138934.1
Coordinates 2020999..2021292 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO331_RS10190 2016286..2017644 - 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SaO331_RS10195 2017659..2018729 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
SaO331_RS10200 2019047..2020249 + 1203 WP_001109939.1 rod shape-determining protein RodA -
SaO331_RS10205 2020513..2020650 - 138 WP_000828354.1 hypothetical protein -
SaO331_RS10210 2020778..2020987 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
SaO331_RS10215 2020999..2021292 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
SaO331_RS10220 2021458..2022942 + 1485 WP_000571549.1 cardiolipin synthase -
SaO331_RS10225 2022970..2023617 + 648 WP_001187610.1 HD domain-containing protein -
SaO331_RS10250 2024432..2025304 - 873 WP_000725802.1 membrane protein insertase YidC -
SaO331_RS10255 2025390..2026031 - 642 WP_000483147.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T120907 WP_000581792.1 NZ_CP038269:c2020987-2020778 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T120907 NZ_CP038269:c2020987-2020778 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCATATGAAACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT120907 WP_000138934.1 NZ_CP038269:c2021292-2020999 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT120907 NZ_CP038269:c2021292-2020999 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References