Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 807599..808076 Replicon chromosome
Accession NZ_CP038269
Organism Staphylococcus aureus strain O331 isolate B114

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SaO331_RS03950 Protein ID WP_000052076.1
Coordinates 807599..807787 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SaO331_RS03955 Protein ID WP_001059690.1
Coordinates 807816..808076 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO331_RS03915 803637..804107 + 471 WP_000824462.1 hypothetical protein -
SaO331_RS03920 804448..805134 + 687 WP_001823812.1 thermonuclease family protein -
SaO331_RS03925 805491..805691 + 201 WP_001059082.1 cold-shock protein -
SaO331_RS03935 806190..806408 - 219 WP_000005888.1 hypothetical protein -
SaO331_RS03940 806470..806754 - 285 WP_001004397.1 hypothetical protein -
SaO331_RS03945 806842..807411 - 570 WP_001106657.1 hypothetical protein -
SaO331_RS03950 807599..807787 - 189 WP_000052076.1 hypothetical protein Toxin
SaO331_RS03955 807816..808076 - 261 WP_001059690.1 hypothetical protein Antitoxin
SaO331_RS03960 808417..808620 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SaO331_RS03965 808617..808853 - 237 WP_000368687.1 hypothetical protein -
SaO331_RS03970 809073..809654 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
SaO331_RS03975 809727..810344 - 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
SaO331_RS03980 810500..810994 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
SaO331_RS03985 811393..811815 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
SaO331_RS03990 811963..812679 + 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq / seb 802279..835622 33343


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T120903 WP_000052076.1 NZ_CP038269:c807787-807599 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T120903 NZ_CP038269:c807787-807599 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT120903 WP_001059690.1 NZ_CP038269:c808076-807816 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT120903 NZ_CP038269:c808076-807816 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References