Detailed information of TA system TA120895

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 1312053..1312850
• Replicon: chromosome
• Accession: NZ_CP038268
• Organism: Staphylococcus aureus strain O55 isolate B118

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: SaO55_RS06680
• Protein ID: WP_135789162.1
• Coordinates: 1312053..1312514 (-)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0C2LD36
• Locus tag: SaO55_RS06685
• Protein ID: WP_001260487.1
• Coordinates: 1312527..1312850 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SaO55_RS06660	1308121..1309794	+	1674	WP_001218598.1	glycerol-3-phosphate dehydrogenase/oxidase	-
SaO55_RS06665	1309944..1310366	+	423	Protein_1248	alpha/beta hydrolase	-
SaO55_RS06670	1310426..1311463	-	1038	WP_046597462.1	site-specific integrase	-
SaO55_RS06675	1311541..1312035	-	495	WP_135789161.1	hypothetical protein	-
SaO55_RS06680	1312053..1312514	-	462	WP_135789162.1	toxin	Toxin
SaO55_RS06685	1312527..1312850	-	324	WP_001260487.1	helix-turn-helix domain-containing protein	Antitoxin
SaO55_RS06690	1313014..1313262	+	249	WP_000272858.1	helix-turn-helix domain-containing protein	-
SaO55_RS06695	1313275..1313718	+	444	WP_135789163.1	hypothetical protein	-
SaO55_RS06700	1313733..1313876	+	144	WP_000939498.1	hypothetical protein	-
SaO55_RS06705	1313898..1314488	-	591	WP_135789164.1	hypothetical protein	-
SaO55_RS06710	1314545..1315333	+	789	WP_135789165.1	phage antirepressor	-
SaO55_RS06715	1315349..1315531	+	183	WP_046597466.1	hypothetical protein	-
SaO55_RS06725	1315788..1316108	+	321	WP_046597467.1	DUF771 domain-containing protein	-
SaO55_RS06730	1316105..1316266	+	162	WP_031766022.1	DUF1270 domain-containing protein	-
SaO55_RS06735	1316360..1316662	+	303	WP_046597468.1	DUF2482 family protein	-
SaO55_RS06740	1316667..1316927	+	261	WP_135789166.1	DUF1108 family protein	-
SaO55_RS06745	1316937..1317158	+	222	WP_000815403.1	DUF2483 family protein	-
SaO55_RS06750	1317151..1317774	+	624	WP_000139725.1	DUF1071 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1310426..1349002	38576

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18059.49 Da
• Isoelectric Point: 4.9206

>T120895 WP_135789162.1 NZ_CP038268:c1312514-1312053 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEKYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T120895 NZ_CP038268:c1312514-1312053 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCTGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTTGAAGCTTACAATTATGGCGTACGTAATTTGTATGAGTT
GTCCGAGTACCTACAACTGAGTGAAAAATACATATTAGAAGCGATAGAACAATATAAGAAGATATACGGTATCGGAACTC
ACTACGGCGAATATTCAATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12431.09 Da
• Isoelectric Point: 9.3811

>AT120895 WP_001260487.1 NZ_CP038268:c1312850-1312527 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT120895 NZ_CP038268:c1312850-1312527 [Staphylococcus aureus]
ATGAGAACTTCAGCAGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCCGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGAGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Structures

Antitoxin

• AlphaFold DB: A0A0C2LD36