Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/ParE-YefM |
Location | 12909..13480 | Replicon | plasmid pEC_mcr4.3 |
Accession | NZ_CP038265 | ||
Organism | Acinetobacter baumannii strain LEV1449/17Ec |
Toxin (Protein)
Gene name | parE | Uniprot ID | Q07XG2 |
Locus tag | E4K03_RS19315 | Protein ID | WP_011638897.1 |
Coordinates | 12909..13220 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | Q07XG1 |
Locus tag | E4K03_RS19320 | Protein ID | WP_011638898.1 |
Coordinates | 13220..13480 (-) | Length | 87 a.a. |
Genomic Context
Location: 8387..8596 (210 bp)
Type: Others
Protein ID: WP_034121058.1
Type: Others
Protein ID: WP_034121058.1
Location: 9494..9757 (264 bp)
Type: Others
Protein ID: WP_034121059.1
Type: Others
Protein ID: WP_034121059.1
Location: 13650..14239 (590 bp)
Type: Others
Protein ID: Protein_14
Type: Others
Protein ID: Protein_14
Location: 14413..16038 (1626 bp)
Type: Others
Protein ID: WP_011638903.1
Type: Others
Protein ID: WP_011638903.1
Location: 16240..16890 (651 bp)
Type: Others
Protein ID: WP_052201470.1
Type: Others
Protein ID: WP_052201470.1
Location: 17087..17290 (204 bp)
Type: Others
Protein ID: WP_034121061.1
Type: Others
Protein ID: WP_034121061.1
Location: 17509..17799 (291 bp)
Type: Others
Protein ID: WP_034121062.1
Type: Others
Protein ID: WP_034121062.1
Location: 9799..12885 (3087 bp)
Type: Others
Protein ID: WP_135013714.1
Type: Others
Protein ID: WP_135013714.1
Location: 12909..13220 (312 bp)
Type: Toxin
Protein ID: WP_011638897.1
Type: Toxin
Protein ID: WP_011638897.1
Location: 13220..13480 (261 bp)
Type: Antitoxin
Protein ID: WP_011638898.1
Type: Antitoxin
Protein ID: WP_011638898.1
Location: 17904..18140 (237 bp)
Type: Others
Protein ID: WP_114237987.1
Type: Others
Protein ID: WP_114237987.1
Loading, please wait
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E4K03_RS19300 | 8387..8596 | + | 210 | WP_034121058.1 | hypothetical protein | - |
E4K03_RS19305 | 9494..9757 | + | 264 | WP_034121059.1 | hypothetical protein | - |
E4K03_RS19310 | 9799..12885 | - | 3087 | WP_135013714.1 | Tn3 family transposase | - |
E4K03_RS19315 | 12909..13220 | - | 312 | WP_011638897.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
E4K03_RS19320 | 13220..13480 | - | 261 | WP_011638898.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
E4K03_RS19325 | 13650..14239 | + | 590 | Protein_14 | recombinase family protein | - |
E4K03_RS19330 | 14413..16038 | + | 1626 | WP_011638903.1 | phosphoethanolamine--lipid A transferase MCR-4.3 | - |
E4K03_RS19335 | 16240..16890 | + | 651 | WP_052201470.1 | HNH endonuclease | - |
E4K03_RS19340 | 17087..17290 | + | 204 | WP_034121061.1 | hypothetical protein | - |
E4K03_RS19345 | 17509..17799 | + | 291 | WP_034121062.1 | hypothetical protein | - |
E4K03_RS19350 | 17904..18140 | - | 237 | WP_114237987.1 | hypothetical protein | - |
Associated MGEs
Loading, please wait
MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | mcr-4.3 | - | 1..43093 | 43093 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 11830.64 Da Isoelectric Point: 8.5341
>T120889 WP_011638897.1 NZ_CP038265:c13220-12909 [Acinetobacter baumannii]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRVNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRVNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII
Download Length: 312 bp
>T120889 NZ_CP038265:c13220-12909 [Acinetobacter baumannii]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACATATTTATCAGGACTTAGACAAACGATTCAGCTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCGTGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACATATTTATCAGGACTTAGACAAACGATTCAGCTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCGTGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9330.74 Da Isoelectric Point: 6.4546
>AT120889 WP_011638898.1 NZ_CP038265:c13480-13220 [Acinetobacter baumannii]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAMTDIKMGNLVDGNTFFDEL
AAGQYD
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAMTDIKMGNLVDGNTFFDEL
AAGQYD
Download Length: 261 bp
>AT120889 NZ_CP038265:c13480-13220 [Acinetobacter baumannii]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCGTACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATGACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCGTACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATGACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA
Structures
Toxin
Loading, please wait
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A883CRN5 |
Antitoxin
Loading, please wait
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2K8ZVH1 |