Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 12909..13480 Replicon plasmid pEC_mcr4.3
Accession NZ_CP038265
Organism Acinetobacter baumannii strain LEV1449/17Ec

Toxin (Protein)


Gene name parE Uniprot ID Q07XG2
Locus tag E4K03_RS19315 Protein ID WP_011638897.1
Coordinates 12909..13220 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q07XG1
Locus tag E4K03_RS19320 Protein ID WP_011638898.1
Coordinates 13220..13480 (-) Length 87 a.a.

Genomic Context


E4K03_RS19300E4K03_RS19305E4K03_RS19325E4K03_RS19330E4K03_RS19335E4K03_RS19340E4K03_RS19345E4K03_RS19310E4K03_RS19315E4K03_RS19320E4K03_RS19350
Location: 8387..8596 (210 bp)
Type: Others
Protein ID: WP_034121058.1
Location: 9494..9757 (264 bp)
Type: Others
Protein ID: WP_034121059.1
Location: 13650..14239 (590 bp)
Type: Others
Protein ID: Protein_14
Location: 14413..16038 (1626 bp)
Type: Others
Protein ID: WP_011638903.1
Location: 16240..16890 (651 bp)
Type: Others
Protein ID: WP_052201470.1
Location: 17087..17290 (204 bp)
Type: Others
Protein ID: WP_034121061.1
Location: 17509..17799 (291 bp)
Type: Others
Protein ID: WP_034121062.1
Location: 9799..12885 (3087 bp)
Type: Others
Protein ID: WP_135013714.1
Location: 12909..13220 (312 bp)
Type: Toxin
Protein ID: WP_011638897.1
Location: 13220..13480 (261 bp)
Type: Antitoxin
Protein ID: WP_011638898.1
Location: 17904..18140 (237 bp)
Type: Others
Protein ID: WP_114237987.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
E4K03_RS193008387..8596+210WP_034121058.1hypothetical protein-
E4K03_RS193059494..9757+264WP_034121059.1hypothetical protein-
E4K03_RS193109799..12885-3087WP_135013714.1Tn3 family transposase-
E4K03_RS1931512909..13220-312WP_011638897.1type II toxin-antitoxin system RelE/ParE family toxinToxin
E4K03_RS1932013220..13480-261WP_011638898.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
E4K03_RS1932513650..14239+590Protein_14recombinase family protein-
E4K03_RS1933014413..16038+1626WP_011638903.1phosphoethanolamine--lipid A transferase MCR-4.3-
E4K03_RS1933516240..16890+651WP_052201470.1HNH endonuclease-
E4K03_RS1934017087..17290+204WP_034121061.1hypothetical protein-
E4K03_RS1934517509..17799+291WP_034121062.1hypothetical protein-
E4K03_RS1935017904..18140-237WP_114237987.1hypothetical protein-

Associated MGEs


Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidmcr-4.3-1..4309343093


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 11830.64 Da        Isoelectric Point: 8.5341

>T120889 WP_011638897.1 NZ_CP038265:c13220-12909 [Acinetobacter baumannii]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRVNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T120889 NZ_CP038265:c13220-12909 [Acinetobacter baumannii]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACATATTTATCAGGACTTAGACAAACGATTCAGCTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCGTGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9330.74 Da        Isoelectric Point: 6.4546

>AT120889 WP_011638898.1 NZ_CP038265:c13480-13220 [Acinetobacter baumannii]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAMTDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT120889 NZ_CP038265:c13480-13220 [Acinetobacter baumannii]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCGTACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATGACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins


Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A883CRN5


Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A2K8ZVH1

References