Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 12909..13480 Replicon plasmid pEC_mcr4.3
Accession NZ_CP038265
Organism Acinetobacter baumannii strain LEV1449/17Ec

Toxin (Protein)


Gene name parE Uniprot ID Q07XG2
Locus tag E4K03_RS19315 Protein ID WP_011638897.1
Coordinates 12909..13220 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q07XG1
Locus tag E4K03_RS19320 Protein ID WP_011638898.1
Coordinates 13220..13480 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4K03_RS19300 8387..8596 + 210 WP_034121058.1 hypothetical protein -
E4K03_RS19305 9494..9757 + 264 WP_034121059.1 hypothetical protein -
E4K03_RS19310 9799..12885 - 3087 WP_135013714.1 Tn3 family transposase -
E4K03_RS19315 12909..13220 - 312 WP_011638897.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4K03_RS19320 13220..13480 - 261 WP_011638898.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E4K03_RS19325 13650..14239 + 590 Protein_14 recombinase family protein -
E4K03_RS19330 14413..16038 + 1626 WP_011638903.1 phosphoethanolamine--lipid A transferase MCR-4.3 -
E4K03_RS19335 16240..16890 + 651 WP_052201470.1 HNH endonuclease -
E4K03_RS19340 17087..17290 + 204 WP_034121061.1 hypothetical protein -
E4K03_RS19345 17509..17799 + 291 WP_034121062.1 hypothetical protein -
E4K03_RS19350 17904..18140 - 237 WP_114237987.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-4.3 - 1..43093 43093


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-62)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11830.64 Da        Isoelectric Point: 8.5341

>T120889 WP_011638897.1 NZ_CP038265:c13220-12909 [Acinetobacter baumannii]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRVNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T120889 NZ_CP038265:c13220-12909 [Acinetobacter baumannii]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACATATTTATCAGGACTTAGACAAACGATTCAGCTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCGTGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9330.74 Da        Isoelectric Point: 6.4546

>AT120889 WP_011638898.1 NZ_CP038265:c13480-13220 [Acinetobacter baumannii]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAMTDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT120889 NZ_CP038265:c13480-13220 [Acinetobacter baumannii]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCGTACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATGACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A883CRN5

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8ZVH1

References