Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 6603..7128 Replicon plasmid pEC_mcr4.3
Accession NZ_CP038265
Organism Acinetobacter baumannii strain LEV1449/17Ec

Toxin (Protein)


Gene name relE Uniprot ID R9B9L0
Locus tag E4K03_RS19280 Protein ID WP_005134734.1
Coordinates 6603..6890 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3F3MMG8
Locus tag E4K03_RS19285 Protein ID WP_005134732.1
Coordinates 6880..7128 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4K03_RS19265 3609..4828 + 1220 WP_087486619.1 IS3-like element ISAba19 family transposase -
E4K03_RS19270 4858..5112 + 255 Protein_3 DNA polymerase V -
E4K03_RS19275 5143..6438 + 1296 WP_128202065.1 Y-family DNA polymerase -
E4K03_RS19280 6603..6890 - 288 WP_005134734.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4K03_RS19285 6880..7128 - 249 WP_005134732.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E4K03_RS19290 7131..7562 - 432 WP_123794408.1 hypothetical protein -
E4K03_RS19295 7632..8246 - 615 WP_123794409.1 recombinase family protein -
E4K03_RS19300 8387..8596 + 210 WP_034121058.1 hypothetical protein -
E4K03_RS19305 9494..9757 + 264 WP_034121059.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-4.3 - 1..43093 43093


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11073.89 Da        Isoelectric Point: 10.1961

>T120888 WP_005134734.1 NZ_CP038265:c6890-6603 [Acinetobacter baumannii]
MTYKLDFLEEALAEWNKLNPSIKQPLKKKLIKVLENPRIPKNKLSGHPNRYKIKLRSIGYRLVYEVIDDEVVVIVIAVGR
RENNAVYDDANSRHS

Download         Length: 288 bp

>T120888 NZ_CP038265:c6890-6603 [Acinetobacter baumannii]
ATGACCTATAAGTTAGACTTTTTAGAAGAAGCATTAGCAGAATGGAATAAGCTTAATCCAAGTATTAAGCAGCCATTAAA
GAAGAAGTTGATCAAGGTTTTGGAGAATCCTCGCATTCCCAAAAACAAGCTGTCAGGACATCCTAATCGCTACAAGATCA
AACTTCGCAGCATTGGTTATCGTTTGGTTTATGAAGTCATTGATGATGAAGTAGTTGTCATCGTAATTGCTGTAGGCAGA
CGTGAAAACAATGCCGTCTATGATGATGCCAACTCTCGTCATTCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9262.72 Da        Isoelectric Point: 5.0491

>AT120888 WP_005134732.1 NZ_CP038265:c7128-6880 [Acinetobacter baumannii]
MTQLIHARMTASITELKKSPMDTVLAGKGEPVAILNRNTPAFYCVPADLYETMMEQLEDLELNKIADTRANQKRVRVNID
DL

Download         Length: 249 bp

>AT120888 NZ_CP038265:c7128-6880 [Acinetobacter baumannii]
ATGACTCAATTAATCCATGCACGAATGACTGCAAGTATTACTGAACTCAAAAAGAGTCCGATGGATACAGTGTTGGCAGG
CAAAGGTGAACCTGTTGCAATCCTCAATCGTAATACACCAGCGTTTTACTGTGTTCCGGCTGATCTATATGAAACGATGA
TGGAACAACTAGAAGACCTAGAACTGAATAAGATTGCAGATACTCGTGCGAACCAAAAACGCGTTCGAGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R9B9L0

Antitoxin

Source ID Structure
AlphaFold DB A0A3F3MMG8

References