Detailed information of TA system TA120884

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1986383..1987062
• Replicon: chromosome
• Accession: NZ_CP038262
• Organism: Acinetobacter baumannii strain LEV1449/17Ec

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: E4K03_RS09635
• Protein ID: WP_000838146.1
• Coordinates: 1986383..1986565 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: E4K03_RS09640
• Protein ID: WP_000966688.1
• Coordinates: 1986658..1987062 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4K03_RS19595	1981558..1981728	+	171	WP_005119785.1	hypothetical protein	-
E4K03_RS09595	1981740..1982148	+	409	Protein_1827	hypothetical protein	-
E4K03_RS09600	1982120..1982488	+	369	WP_057692848.1	hypothetical protein	-
E4K03_RS09605	1982490..1982888	+	399	WP_020752910.1	hypothetical protein	-
E4K03_RS09610	1982957..1983310	+	354	WP_060513623.1	hypothetical protein	-
E4K03_RS09615	1983310..1984458	+	1149	WP_135013486.1	phage tail protein	-
E4K03_RS09620	1984555..1985472	+	918	WP_135013488.1	hypothetical protein	-
E4K03_RS09625	1985542..1986057	+	516	WP_032014679.1	hypothetical protein	-
E4K03_RS09635	1986383..1986565	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
E4K03_RS09640	1986658..1987062	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
E4K03_RS09645	1987144..1987521	+	378	WP_000720074.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1948084..2004101	56017

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T120884 WP_000838146.1 NZ_CP038262:1986383-1986565 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T120884 NZ_CP038262:1986383-1986565 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT120884 WP_000966688.1 NZ_CP038262:1986658-1987062 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT120884 NZ_CP038262:1986658-1987062 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6