Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 920224..920877 Replicon chromosome
Accession NZ_CP038262
Organism Acinetobacter baumannii strain LEV1449/17Ec

Toxin (Protein)


Gene name cptA Uniprot ID A0A829RKD8
Locus tag E4K03_RS04545 Protein ID WP_002125600.1
Coordinates 920488..920877 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag E4K03_RS04540 Protein ID WP_001288210.1
Coordinates 920224..920481 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4K03_RS04520 915740..916747 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
E4K03_RS04525 916766..917143 + 378 WP_001216380.1 50S ribosomal protein L17 -
E4K03_RS04530 917325..918815 + 1491 WP_002125480.1 NAD(P)/FAD-dependent oxidoreductase -
E4K03_RS04535 918864..920036 - 1173 WP_002125555.1 acyl-CoA dehydrogenase family protein -
E4K03_RS04540 920224..920481 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
E4K03_RS04545 920488..920877 + 390 WP_002125600.1 hypothetical protein Toxin
E4K03_RS04550 921647..922732 + 1086 WP_000049106.1 hypothetical protein -
E4K03_RS04555 922810..923376 + 567 WP_000651536.1 rhombosortase -
E4K03_RS04560 923564..925756 + 2193 WP_135013450.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15662.98 Da        Isoelectric Point: 10.4623

>T120883 WP_002125600.1 NZ_CP038262:920488-920877 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKIWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T120883 NZ_CP038262:920488-920877 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAAATATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCACGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAAAACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT120883 WP_001288210.1 NZ_CP038262:920224-920481 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT120883 NZ_CP038262:920224-920481 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCATTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829RKD8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References