Detailed information of TA system TA120882

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 800119..800747
• Replicon: chromosome
• Accession: NZ_CP038262
• Organism: Acinetobacter baumannii strain LEV1449/17Ec

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: E4K03_RS03885
• Protein ID: WP_004833671.1
• Coordinates: 800119..800520 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A158LZG4
• Locus tag: E4K03_RS03890
• Protein ID: WP_002125542.1
• Coordinates: 800520..800747 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4K03_RS03860	795800..796687	+	888	WP_004833668.1	metal-dependent hydrolase	-
E4K03_RS03865	796818..797408	+	591	WP_000846931.1	LemA family protein	-
E4K03_RS03870	797430..798512	+	1083	WP_001246384.1	TPM domain-containing protein	-
E4K03_RS03875	798506..799066	+	561	WP_002125582.1	TPM domain-containing protein	-
E4K03_RS03880	799407..799847	+	441	WP_002125488.1	pilin	-
E4K03_RS03885	800119..800520	-	402	WP_004833671.1	type II toxin-antitoxin system VapC family toxin	Toxin
E4K03_RS03890	800520..800747	-	228	WP_002125542.1	hypothetical protein	Antitoxin
E4K03_RS03895	800900..802528	+	1629	WP_109267663.1	O-antigen ligase family protein	-
E4K03_RS03900	802570..803034	-	465	WP_000678123.1	bacterioferritin	-
E4K03_RS03905	803279..803473	-	195	WP_000289091.1	bacterioferritin-associated ferredoxin	-
E4K03_RS03910	803683..804066	-	384	WP_000090000.1	RidA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15100.37 Da
• Isoelectric Point: 7.2756

>T120882 WP_004833671.1 NZ_CP038262:c800520-800119 [Acinetobacter baumannii]
MLRYMLDTNIVIYTIKNKPPEVKVRFNAVATQLCVSSITVAELIYGAENSQNPIKNLRVVEDFLSRLQILDYTPEAAAQY
GMIKADLRRKGTLISDNDTHIAAHARSHGLILVTNNTKEFQRVEALQLENWVE

Nucleotide

• Length: 402 bp

>T120882 NZ_CP038262:c800520-800119 [Acinetobacter baumannii]
ATGTTGAGATATATGTTAGATACCAATATCGTGATCTATACCATCAAAAATAAACCGCCTGAAGTTAAAGTGCGATTTAA
TGCTGTTGCCACTCAGTTATGTGTCAGTAGTATCACTGTGGCAGAACTTATTTATGGTGCAGAAAATAGTCAAAACCCTA
TAAAAAATTTACGCGTTGTCGAAGATTTTTTATCTCGATTACAGATTTTAGATTATACCCCTGAAGCAGCAGCTCAATAT
GGCATGATCAAAGCAGATTTACGTCGTAAAGGCACGCTTATTAGTGATAATGACACGCATATTGCAGCTCATGCTCGTAG
TCATGGTCTTATTTTAGTCACCAACAATACTAAAGAATTTCAAAGAGTCGAAGCTTTACAGTTAGAGAATTGGGTTGAGT
GA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8706.86 Da
• Isoelectric Point: 4.7361

>AT120882 WP_002125542.1 NZ_CP038262:c800747-800520 [Acinetobacter baumannii]
MITSVFTNNRSQAVRLPAIFRFPKETQKVFVRVVGVERVICPVEHIWDSFFDDAQLTVSDDFERGEQIAAERESF

Nucleotide

• Length: 228 bp

>AT120882 NZ_CP038262:c800747-800520 [Acinetobacter baumannii]
ATGATTACATCTGTATTTACAAATAATCGCTCCCAAGCTGTTCGCTTACCAGCTATTTTTCGCTTTCCTAAAGAAACACA
AAAAGTCTTTGTAAGGGTCGTTGGTGTAGAACGCGTCATTTGCCCTGTGGAACATATTTGGGACAGTTTTTTTGATGATG
CTCAACTCACCGTTTCAGATGATTTTGAGCGTGGTGAACAAATTGCAGCGGAGCGTGAGAGTTTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A158LZG4