Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 2393037..2393690 Replicon chromosome
Accession NZ_CP038258
Organism Acinetobacter baumannii strain 39741

Toxin (Protein)


Gene name cptA Uniprot ID A0A829RKD8
Locus tag E4K02_RS11700 Protein ID WP_002125600.1
Coordinates 2393037..2393426 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag E4K02_RS11705 Protein ID WP_001288210.1
Coordinates 2393433..2393690 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4K02_RS11685 2388155..2390350 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
E4K02_RS11690 2390538..2391104 - 567 WP_000651536.1 rhombosortase -
E4K02_RS11695 2391182..2392267 - 1086 WP_000049106.1 hypothetical protein -
E4K02_RS11700 2393037..2393426 - 390 WP_002125600.1 hypothetical protein Toxin
E4K02_RS11705 2393433..2393690 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
E4K02_RS11710 2393878..2395050 + 1173 WP_002125555.1 acyl-CoA dehydrogenase family protein -
E4K02_RS11715 2395099..2396589 - 1491 WP_002125480.1 NAD(P)/FAD-dependent oxidoreductase -
E4K02_RS11720 2396771..2397148 - 378 WP_001216380.1 50S ribosomal protein L17 -
E4K02_RS11725 2397167..2398174 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15662.98 Da        Isoelectric Point: 10.4623

>T120874 WP_002125600.1 NZ_CP038258:c2393426-2393037 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKIWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T120874 NZ_CP038258:c2393426-2393037 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAAATATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCACGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAAAACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT120874 WP_001288210.1 NZ_CP038258:c2393690-2393433 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT120874 NZ_CP038258:c2393690-2393433 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCATTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829RKD8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References