120873

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 1235029..1235689 Replicon chromosome
Accession NZ_CP038256
Organism Microbacterium sediminis strain YLB-01

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B9NG67
Locus tag E3O41_RS05880 Protein ID WP_067022840.1
Coordinates 1235029..1235421 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B9NG91
Locus tag E3O41_RS05885 Protein ID WP_067022843.1
Coordinates 1235426..1235689 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3O41_RS05855 1230632..1231384 + 753 WP_067022825.1 hypothetical protein -
E3O41_RS05860 1231381..1232493 + 1113 WP_067022828.1 o-succinylbenzoate synthase -
E3O41_RS05865 1232517..1233410 + 894 WP_067022832.1 ABC transporter substrate-binding protein -
E3O41_RS05870 1233412..1234266 + 855 WP_067022835.1 amino acid ABC transporter permease -
E3O41_RS05875 1234263..1235027 + 765 WP_135012158.1 amino acid ABC transporter ATP-binding protein -
E3O41_RS05880 1235029..1235421 - 393 WP_067022840.1 type II toxin-antitoxin system VapC family toxin Toxin
E3O41_RS05885 1235426..1235689 - 264 WP_067022843.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
E3O41_RS05890 1235816..1236259 + 444 WP_067022846.1 hypothetical protein -
E3O41_RS05895 1236426..1237529 + 1104 WP_067022849.1 NAD(P)-dependent alcohol dehydrogenase -
E3O41_RS05900 1237679..1238521 - 843 WP_067022852.1 DUF72 domain-containing protein -
E3O41_RS05905 1238575..1238910 + 336 WP_067022855.1 TraR/DksA C4-type zinc finger protein -
E3O41_RS05910 1238911..1239345 - 435 WP_067022858.1 DoxX family membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-41)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13842.63 Da        Isoelectric Point: 4.4500

>T120873 WP_067022840.1 NZ_CP038256:c1235421-1235029 [Microbacterium sediminis]
VAVYVDTSALVKLVVREPESDALVAWAATEAAQAVSADLARTELVRAVRRSNPEQAERARDVLDSVTLLALTPEILESAG
RIEPRGLRSLDAVHLAAALALGDDLDAIVTYDERLAEAARSHGVHVLAPE

Download         Length: 393 bp

>T120873 NZ_CP038256:c1235421-1235029 [Microbacterium sediminis]
GTGGCCGTGTACGTCGACACCTCGGCCCTGGTGAAGCTCGTTGTCCGCGAGCCCGAGTCCGATGCACTCGTCGCGTGGGC
TGCCACCGAGGCCGCGCAGGCTGTGAGCGCGGACCTCGCGCGCACCGAGCTGGTGAGGGCCGTGCGCCGCAGCAACCCGG
AGCAGGCAGAGCGGGCGCGCGATGTGCTCGACAGCGTGACGCTGCTCGCACTGACGCCGGAGATCCTCGAATCAGCGGGG
CGTATCGAACCGCGGGGGCTGCGCAGTCTGGACGCGGTTCATCTCGCAGCCGCGCTGGCCCTGGGGGATGATCTCGACGC
GATCGTCACGTACGACGAGCGGCTCGCCGAGGCGGCACGATCGCACGGCGTGCACGTGCTCGCGCCGGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9290.64 Da        Isoelectric Point: 10.7752

>AT120873 WP_067022843.1 NZ_CP038256:c1235689-1235426 [Microbacterium sediminis]
MNEVGIRELKQNASAVVARVAEGETLTVTDRRRPVAQLIPLGGGRLSQLVASGQARPAKRPLGELGVPTVGGDLTSPLRA
MRDDERY

Download         Length: 264 bp

>AT120873 NZ_CP038256:c1235689-1235426 [Microbacterium sediminis]
ATGAACGAAGTGGGCATCCGAGAGCTGAAGCAGAATGCGTCGGCGGTGGTCGCTCGGGTAGCGGAGGGTGAGACGTTGAC
GGTCACCGATCGGCGCCGCCCCGTCGCGCAGCTCATTCCTCTGGGTGGAGGTCGTCTCTCCCAGCTGGTTGCATCCGGTC
AGGCTCGGCCGGCGAAGCGTCCCCTCGGGGAGCTCGGAGTACCCACCGTCGGCGGCGACCTCACCTCACCGCTTCGTGCC
ATGCGCGACGACGAGAGGTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B9NG67

Antitoxin

Source ID Structure
AlphaFold DB A0A1B9NG91

References