Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3447211..3447842 Replicon chromosome
Accession NZ_CP038255
Organism Terasakiella sp. SH-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E4K71_RS16215 Protein ID WP_135081333.1
Coordinates 3447441..3447842 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E4K71_RS16210 Protein ID WP_135081331.1
Coordinates 3447211..3447441 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4K71_RS16190 3442834..3443376 + 543 WP_135081325.1 DUF4405 domain-containing protein -
E4K71_RS16195 3443486..3445309 + 1824 WP_135081326.1 translational GTPase TypA -
E4K71_RS16200 3445442..3446332 + 891 WP_135081327.1 DMT family transporter -
E4K71_RS16205 3446372..3447142 + 771 WP_135081329.1 (Fe-S)-binding protein -
E4K71_RS16210 3447211..3447441 + 231 WP_135081331.1 antitoxin Antitoxin
E4K71_RS16215 3447441..3447842 + 402 WP_135081333.1 tRNA(fMet)-specific endonuclease VapC Toxin
E4K71_RS16220 3447843..3449267 + 1425 WP_135081335.1 iron-sulfur cluster-binding protein -
E4K71_RS16225 3449264..3449941 + 678 WP_135081337.1 lactate utilization protein -
E4K71_RS16230 3449934..3450518 + 585 WP_135081339.1 Smr/MutS family protein -
E4K71_RS16235 3450543..3450905 + 363 WP_135081341.1 helix-turn-helix domain-containing protein -
E4K71_RS16240 3450911..3451837 + 927 WP_135081342.1 hypothetical protein -
E4K71_RS16245 3451842..3452258 + 417 WP_167730640.1 GtrA family protein -
E4K71_RS16250 3452252..3452671 - 420 WP_135081346.1 group III truncated hemoglobin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-33)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15190.48 Da        Isoelectric Point: 6.8643

>T120872 WP_135081333.1 NZ_CP038255:3447441-3447842 [Terasakiella sp. SH-1]
MLRYMLDTNICIFVIKNRPEHMRAVFNEKSHSMCVSAITVAELIYGAEKSVQKEKNLKVVEGFLSRLETLDFDEEAANHY
GEIRAALEKKGLPIGPYDLMLAGHSRSRGLVMVTNNTREFSRVDGLRLEDWSQ

Download         Length: 402 bp

>T120872 NZ_CP038255:3447441-3447842 [Terasakiella sp. SH-1]
ATGTTACGCTATATGCTGGATACGAACATTTGTATTTTTGTGATTAAAAACCGCCCTGAACATATGCGCGCTGTTTTTAA
TGAAAAATCTCATTCTATGTGTGTATCCGCCATTACTGTTGCTGAATTGATCTATGGTGCTGAAAAATCAGTACAAAAAG
AGAAAAACCTGAAAGTGGTTGAGGGTTTTTTGTCCCGCCTTGAAACTCTTGATTTTGATGAGGAAGCGGCAAACCATTAC
GGCGAGATTCGTGCTGCGCTTGAAAAAAAAGGTTTACCTATCGGGCCTTATGATTTGATGTTGGCAGGACATTCGCGTTC
ACGTGGTTTGGTGATGGTGACAAATAATACACGGGAATTTTCCCGTGTTGATGGGTTACGTTTAGAGGATTGGAGTCAAT
AA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.87 Da        Isoelectric Point: 4.5535

>AT120872 WP_135081331.1 NZ_CP038255:3447211-3447441 [Terasakiella sp. SH-1]
MTQSSVFKNNQTQAVRIPKAVALPEHIKKVDVIKQGNARLIVPSDCLWDSFFDGEQPSDDFMVERSEPEMQVREEL

Download         Length: 231 bp

>AT120872 NZ_CP038255:3447211-3447441 [Terasakiella sp. SH-1]
ATGACACAGAGCAGTGTATTTAAGAATAATCAAACACAAGCTGTTCGTATCCCTAAGGCTGTTGCATTACCGGAACATAT
AAAAAAGGTGGATGTCATCAAACAGGGGAATGCACGCCTTATTGTGCCCAGTGATTGTCTTTGGGACAGTTTTTTCGATG
GAGAGCAGCCAAGCGATGATTTTATGGTTGAGCGCTCTGAACCTGAAATGCAGGTGCGTGAGGAACTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References