Detailed information of TA system TA120869

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1204696..1205294
• Replicon: chromosome
• Accession: NZ_CP038254
• Organism: Legionella israelensis strain HL-0427-4011

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: E3983_RS05420
• Protein ID: WP_135060159.1
• Coordinates: 1204696..1204893 (+)
• Length: 66 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: E3983_RS05425
• Protein ID: WP_135060160.1
• Coordinates: 1204890..1205294 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3983_RS05395	1200009..1200518	+	510	WP_135060154.1	hypothetical protein	-
E3983_RS05400	1200708..1201082	-	375	WP_135060155.1	IS3 family transposase	-
E3983_RS05405	1201291..1202289	+	999	WP_135060156.1	F-box protein	-
E3983_RS05410	1202588..1203247	-	660	WP_135060157.1	tetratricopeptide repeat protein	-
E3983_RS05415	1204021..1204476	-	456	WP_135060158.1	hypothetical protein	-
E3983_RS05420	1204696..1204893	+	198	WP_135060159.1	type II toxin-antitoxin system HicA family toxin	Toxin
E3983_RS05425	1204890..1205294	+	405	WP_135060160.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
E3983_RS05435	1207522..1207866	+	345	WP_135060161.1	type II toxin-antitoxin system RelE/ParE family toxin	-
E3983_RS05440	1207893..1208216	+	324	WP_135060162.1	XRE family transcriptional regulator	-
E3983_RS05445	1208522..1209775	+	1254	WP_135060163.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7360.76 Da
• Isoelectric Point: 10.7302

>T120869 WP_135060159.1 NZ_CP038254:1204696-1204893 [Legionella israelensis]
MKSAEIIKIIERDGWVKCHQKGSHCQFKHPVKKGRVTVPHPKKDLPVKTVASIFKQAGLSKEDIK

Nucleotide

• Length: 198 bp

>T120869 NZ_CP038254:1204696-1204893 [Legionella israelensis]
ATGAAAAGCGCAGAAATAATAAAAATAATTGAGCGTGACGGCTGGGTGAAATGCCATCAAAAAGGCAGTCATTGTCAGTT
CAAACACCCGGTAAAAAAGGGAAGGGTAACGGTACCTCATCCTAAAAAAGACTTGCCTGTTAAAACGGTTGCCAGCATTT
TTAAGCAGGCTGGCCTTAGTAAGGAGGATATAAAATGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14964.83 Da
• Isoelectric Point: 4.3465

>AT120869 WP_135060160.1 NZ_CP038254:1204890-1205294 [Legionella israelensis]
MRYPVVIHKDENSDFGVMVPDIAGCYSAGNTYDEALNNVIEAIECHLEGLLLDNESIPVGSSMDSWVDNEEFKEGVWAFV
DIDLSQISGKAKRVNITIPERVLNLIDLYAKSHSIKNRSSFLADAALSYMENHK

Nucleotide

• Length: 405 bp

>AT120869 NZ_CP038254:1204890-1205294 [Legionella israelensis]
ATGAGATATCCAGTTGTTATACATAAAGACGAAAACAGCGATTTTGGCGTTATGGTCCCAGATATCGCTGGCTGTTATTC
AGCAGGAAATACTTATGATGAAGCACTGAATAATGTGATAGAGGCTATTGAATGTCATCTTGAAGGGCTGTTGTTGGATA
ATGAGTCTATACCGGTTGGTTCATCGATGGATTCCTGGGTTGACAACGAAGAATTCAAAGAGGGTGTATGGGCATTTGTT
GATATAGATTTAAGCCAGATATCGGGTAAGGCAAAACGTGTAAATATTACCATACCAGAGCGAGTGTTAAATCTGATTGA
TCTCTATGCAAAAAGTCACTCAATAAAGAACCGATCTTCTTTTCTTGCTGATGCTGCTCTTAGTTATATGGAAAACCATA
AATAA