Detailed information of TA system TA120868

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prpT-prpA/ParE-CC2985
• Location: 1116557..1117097
• Replicon: chromosome
• Accession: NZ_CP038254
• Organism: Legionella israelensis strain HL-0427-4011

Toxin (Protein)

• Gene name: PrpT
• Uniprot ID: -
• Locus tag: E3983_RS04970
• Protein ID: WP_135060092.1
• Coordinates: 1116801..1117097 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PrpA
• Uniprot ID: -
• Locus tag: E3983_RS04965
• Protein ID: WP_135060091.1
• Coordinates: 1116557..1116811 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3983_RS04925	1112083..1112478	-	396	WP_135060083.1	hypothetical protein	-
E3983_RS04930	1112842..1113168	-	327	WP_135060084.1	exopolysaccharide biosynthesis protein	-
E3983_RS04935	1113181..1113888	-	708	WP_135060085.1	CBS domain-containing protein	-
E3983_RS04940	1113842..1114084	-	243	WP_167554531.1	DUF21 domain-containing protein	-
E3983_RS04945	1114379..1114963	-	585	WP_135060087.1	DUF4113 domain-containing protein	-
E3983_RS04950	1115090..1115248	+	159	WP_135060088.1	antirestriction protein	-
E3983_RS04955	1115347..1115658	+	312	WP_135060089.1	type II toxin-antitoxin system RelE/ParE family toxin	-
E3983_RS04960	1115668..1115958	+	291	WP_135060090.1	helix-turn-helix domain-containing protein	-
E3983_RS04965	1116557..1116811	+	255	WP_135060091.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
E3983_RS04970	1116801..1117097	+	297	WP_135060092.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E3983_RS04975	1117380..1117808	+	429	WP_135061461.1	hypothetical protein	-
E3983_RS13405	1117819..1118241	-	423	Protein_976	DUF3987 domain-containing protein	-
E3983_RS04985	1118303..1118899	-	597	WP_135060094.1	site-specific integrase	-
E3983_RS04990	1119046..1119912	-	867	WP_135060095.1	AAA family ATPase	-
E3983_RS04995	1119905..1121353	-	1449	WP_135060096.1	DDE-type integrase/transposase/recombinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1113842..1122193	8351

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11837.53 Da
• Isoelectric Point: 7.9055

>T120868 WP_135060092.1 NZ_CP038254:1116801-1117097 [Legionella israelensis]
MQNKTYRLYPKAVEDIENIYVYSVKEFGYDRADDYIYKLEQCFKHLSSEPEIARKCDYIRQNLRAYNVGSHIIFFKETSS
TIVIIRILHKSMDHERHL

Nucleotide

• Length: 297 bp

>T120868 NZ_CP038254:1116801-1117097 [Legionella israelensis]
ATGCAAAATAAAACGTATCGTTTATATCCTAAGGCTGTAGAAGATATCGAAAATATCTATGTTTACTCTGTGAAAGAATT
TGGTTATGACAGAGCAGATGATTATATCTACAAACTGGAACAGTGCTTTAAGCATCTTTCATCGGAGCCTGAAATTGCAA
GGAAGTGTGACTATATTCGTCAAAATTTGCGAGCATATAATGTTGGATCGCATATTATCTTTTTTAAAGAAACGAGTTCA
ACGATTGTTATCATAAGAATTTTACATAAATCTATGGACCACGAGCGCCATTTATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9680.91 Da
• Isoelectric Point: 8.5454

>AT120868 WP_135060091.1 NZ_CP038254:1116557-1116811 [Legionella israelensis]
MARTMTVDLGNELRDYVESLVSSGDYRSNSEVLRESLRLLRERQASSKLELLRRFIDEGESSGKPVDWNADNFLTSMKRK
LNAK

Nucleotide

• Length: 255 bp

>AT120868 NZ_CP038254:1116557-1116811 [Legionella israelensis]
ATGGCGCGAACAATGACAGTCGATCTTGGGAATGAATTAAGAGATTATGTTGAATCTTTGGTAAGCTCTGGTGATTATAG
AAGTAATAGTGAAGTATTGAGAGAGTCGTTACGTTTGCTTCGAGAAAGGCAAGCATCGTCCAAATTGGAATTGCTTAGGC
GATTTATAGATGAGGGTGAAAGCAGTGGTAAGCCGGTAGATTGGAACGCTGATAATTTTTTAACGAGCATGAAAAGAAAA
TTAAATGCAAAATAA