Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1154411..1154909 Replicon chromosome
Accession NZ_CP038253
Organism Streptococcus pneumoniae strain TVO_1901929

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag ES298_RS05725 Protein ID WP_001809704.1
Coordinates 1154411..1154665 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag ES298_RS05730 Protein ID WP_000208080.1
Coordinates 1154667..1154909 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES298_RS05710 (ES298_06030) 1149684..1152152 - 2469 WP_001152990.1 DNA gyrase subunit A -
ES298_RS05715 (ES298_06035) 1152346..1153332 + 987 WP_000204727.1 L-lactate dehydrogenase -
ES298_RS05720 (ES298_06040) 1153669..1154364 - 696 WP_000731137.1 potassium channel family protein -
ES298_RS05725 (ES298_06045) 1154411..1154665 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ES298_RS05730 (ES298_06050) 1154667..1154909 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
ES298_RS05735 (ES298_06055) 1155103..1156359 + 1257 WP_000530078.1 ISL3 family transposase -
ES298_RS05740 (ES298_06060) 1156423..1157232 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
ES298_RS05745 (ES298_06065) 1157234..1158583 - 1350 WP_000886213.1 cell wall metabolism sensor histidine kinase VicK -
ES298_RS05750 (ES298_06070) 1158576..1159280 - 705 WP_000722076.1 response regulator YycF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1155103..1156359 1256


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T120864 WP_001809704.1 NZ_CP038253:c1154665-1154411 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T120864 NZ_CP038253:c1154665-1154411 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT120864 WP_000208080.1 NZ_CP038253:c1154909-1154667 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT120864 NZ_CP038253:c1154909-1154667 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References