120863

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 966601..967835 Replicon chromosome
Accession NZ_CP038253
Organism Streptococcus pneumoniae strain TVO_1901929

Toxin (Protein)


Gene name zeta Uniprot ID A0A0T8STN7
Locus tag ES298_RS04915 Protein ID WP_000405351.1
Coordinates 967077..967835 (+) Length 253 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A0T7YHJ0
Locus tag ES298_RS04910 Protein ID WP_000579620.1
Coordinates 966601..967077 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES298_RS04890 (ES298_05145) 961674..962528 + 855 WP_000901913.1 ADP-ribosylglycohydrolase family protein -
ES298_RS04895 (ES298_05150) 962640..963524 + 885 WP_000757475.1 diacylglycerol kinase family lipid kinase -
ES298_RS04900 (ES298_05160) 963687..965426 + 1740 Protein_976 glycoside hydrolase family 13 protein -
ES298_RS04905 (ES298_05165) 965701..966156 + 456 WP_000500478.1 hypothetical protein -
ES298_RS04910 (ES298_05170) 966601..967077 + 477 WP_000579620.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
ES298_RS04915 (ES298_05175) 967077..967835 + 759 WP_000405351.1 type II toxin-antitoxin system toxin PezT Toxin
ES298_RS04920 (ES298_05180) 968233..969129 - 897 WP_000384879.1 tyrosine-type recombinase/integrase -
ES298_RS04925 (ES298_05185) 969459..971228 + 1770 WP_000002882.1 DUF4365 domain-containing protein -
ES298_RS04930 (ES298_05190) 971257..971541 + 285 WP_000403447.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 957812..1007097 49285


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 253 a.a.        Molecular weight: 28752.57 Da        Isoelectric Point: 6.5919

>T120863 WP_000405351.1 NZ_CP038253:967077-967835 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFESIQIYQRDRSCVYDSKENTTSAATVLHDLLFGELNQVEKEML
KSGEERLKDLTN

Download         Length: 759 bp

>T120863 NZ_CP038253:967077-967835 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAACCTATAGCGATTTTGCTTGGAGGTCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATACACCAAAGATTTTGCAGGGAAAATGGTAGAGTCTTTAGTAACCGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACTATTGATGTTCCAAAGAAAACAGCACAACTATTAAAAAATA
AGGGGTATGAGGTACAATTAGCCTTAATTGCAACCAAGCCCGAATTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTGTATGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTGGCTATCTTTGAAAGCATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAACCGTTCTTCATGATTTACTATTTGGAGAATTGAATCAAGTGGAGAAAGAGATGCTT
AAATCAGGAGAAGAAAGATTGAAAGATTTAACTAATTGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18235.65 Da        Isoelectric Point: 4.3462

>AT120863 WP_000579620.1 NZ_CP038253:966601-967077 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT120863 NZ_CP038253:966601-967077 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACCCGAATTTGCAAGGATTGTAGGTATTTC
ACGAAATAGTCTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATCGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGTATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCAGACAAATATCTATTTAGTAGAAAATTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T8STN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0T7YHJ0

References