Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1521122..1521620 Replicon chromosome
Accession NZ_CP038252
Organism Streptococcus pneumoniae strain TVO_1901936

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag ES276_RS07720 Protein ID WP_001809704.1
Coordinates 1521122..1521376 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag ES276_RS07725 Protein ID WP_000208080.1
Coordinates 1521378..1521620 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES276_RS07715 (ES276_08240) 1519176..1521047 - 1872 WP_000150986.1 Eco57I restriction-modification methylase domain-containing protein -
ES276_RS07720 (ES276_08245) 1521122..1521376 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ES276_RS07725 (ES276_08250) 1521378..1521620 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
ES276_RS07730 (ES276_08255) 1521711..1522520 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
ES276_RS07735 (ES276_08260) 1522522..1523871 - 1350 WP_000886219.1 cell wall metabolism sensor histidine kinase VicK -
ES276_RS07740 (ES276_08265) 1523864..1524568 - 705 WP_000722076.1 response regulator YycF -
ES276_RS07745 (ES276_08270) 1524624..1525799 - 1176 WP_000886146.1 A/G-specific adenine glycosylase -
ES276_RS10865 1525896..1526021 + 126 WP_001818232.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T120862 WP_001809704.1 NZ_CP038252:c1521376-1521122 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T120862 NZ_CP038252:c1521376-1521122 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT120862 WP_000208080.1 NZ_CP038252:c1521620-1521378 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT120862 NZ_CP038252:c1521620-1521378 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References