Detailed information of TA system TA120861

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 1428415..1429652
• Replicon: chromosome
• Accession: NZ_CP038252
• Organism: Streptococcus pneumoniae strain TVO_1901936

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: Q97QZ1
• Locus tag: ES276_RS07275
• Protein ID: WP_000405360.1
• Coordinates: 1428415..1429176 (-)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: ES276_RS07280
• Protein ID: WP_000579608.1
• Coordinates: 1429176..1429652 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ES276_RS07250 (ES276_07750)	1423864..1425687	-	1824	WP_000237144.1	SAG1250 family conjugative relaxase	-
ES276_RS07255 (ES276_07755)	1425674..1426039	-	366	WP_000401239.1	MobC family plasmid mobilization relaxosome protein	-
ES276_RS07260 (ES276_07760)	1426044..1426400	-	357	WP_000817623.1	SAG1252 family conjugative relaxosome accessory protein	-
ES276_RS07265	1427231..1427608	-	378	WP_000530001.1	hypothetical protein	-
ES276_RS07270 (ES276_07770)	1427611..1428387	-	777	WP_001821017.1	hypothetical protein	-
ES276_RS07275 (ES276_07775)	1428415..1429176	-	762	WP_000405360.1	type II toxin-antitoxin system toxin PezT	Toxin
ES276_RS07280 (ES276_07780)	1429176..1429652	-	477	WP_000579608.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
ES276_RS07285	1430097..1430552	-	456	Protein_1422	hypothetical protein	-
ES276_RS07290 (ES276_07795)	1430827..1432566	-	1740	Protein_1423	glycoside hydrolase family 13 protein	-
ES276_RS07295 (ES276_07800)	1432729..1433613	-	885	WP_000710115.1	diacylglycerol kinase family lipid kinase	-
ES276_RS07300 (ES276_07805)	1433725..1434579	-	855	WP_000900015.1	ADP-ribosylglycohydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1416693..1444908	28215

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29129.20 Da
• Isoelectric Point: 7.5087

>T120861 WP_000405360.1 NZ_CP038252:c1429176-1428415 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Nucleotide

• Length: 762 bp

>T120861 NZ_CP038252:c1429176-1428415 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGAGATACAATCTTTTGATAGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAATTGTCGTATCTAAGTACTCTTATCCGTTATGAAGAA
CTGTACATTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
CACACGAAAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCAAGAGTTACTCTTTGGGGAGTGGAGTCAGGTAGAGAAGGAGATGTTG
CAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18247.70 Da
• Isoelectric Point: 4.4188

>AT120861 WP_000579608.1 NZ_CP038252:c1429652-1429176 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQLEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT120861 NZ_CP038252:c1429652-1429176 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTGCGTAAAACACATGACTTAACACAACTCGAATTTGCACGGATTGTAGGTATTTC
ACGAAATAGTCTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
GTCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGATTTGATTCATACGAATATCTATCTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGTGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTGGCCTAA

Structures

Toxin

• PDB: 2P5T