Detailed information of TA system TA120859

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 487751..488419
• Replicon: chromosome
• Accession: NZ_CP038252
• Organism: Streptococcus pneumoniae strain TVO_1901936

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: ES276_RS02690
• Protein ID: WP_001132277.1
• Coordinates: 487751..487930 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: ES276_RS02695
• Protein ID: WP_000961815.1
• Coordinates: 487967..488419 (+)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ES276_RS02655 (ES276_02815)	483554..483967	+	414	WP_000794284.1	hypothetical protein	-
ES276_RS02660 (ES276_02820)	484218..484793	+	576	WP_000810872.1	hypothetical protein	-
ES276_RS02665 (ES276_02825)	484912..485070	+	159	Protein_496	site-specific integrase	-
ES276_RS02675 (ES276_02835)	485490..486761	-	1272	WP_001113180.1	replication-associated recombination protein A	-
ES276_RS02680 (ES276_02845)	487031..487270	+	240	WP_000818079.1	hypothetical protein	-
ES276_RS02685 (ES276_02855)	487435..487614	+	180	WP_001809903.1	hypothetical protein	-
ES276_RS02690 (ES276_02860)	487751..487930	+	180	WP_001132277.1	type II toxin-antitoxin system HicA family toxin	Toxin
ES276_RS02695 (ES276_02865)	487967..488419	+	453	WP_000961815.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ES276_RS02700 (ES276_02870)	488710..489180	+	471	WP_000257089.1	DUF3013 family protein	-
ES276_RS02705 (ES276_02875)	489199..490287	+	1089	WP_000719722.1	site-2 protease family protein	-
ES276_RS02710 (ES276_02880)	490268..490696	+	429	WP_000418168.1	NUDIX hydrolase	-
ES276_RS02715 (ES276_02885)	490832..491782	+	951	WP_000451153.1	50S ribosomal protein L11 methyltransferase	-
ES276_RS02720 (ES276_02890)	491784..492527	+	744	WP_001188203.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6629.86 Da
• Isoelectric Point: 11.0962

>T120859 WP_001132277.1 NZ_CP038252:487751-487930 [Streptococcus pneumoniae]
MPMTQKEMVKLFTAHGWIKTRGGKGSHIKIEKQGERPITILHGKLNKYTERGIGKQAGL

Nucleotide

• Length: 180 bp

>T120859 NZ_CP038252:487751-487930 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCTTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAG
GAAAGCAAGCTGGGTTGTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16587.39 Da
• Isoelectric Point: 3.7412

>AT120859 WP_000961815.1 NZ_CP038252:487967-488419 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFGYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT120859 NZ_CP038252:487967-488419 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGGATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA