Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1599204..1599872 Replicon chromosome
Accession NZ_CP038251
Organism Streptococcus pneumoniae strain TVO_1901944

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag ES300_RS08020 Protein ID WP_001132282.1
Coordinates 1599693..1599872 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag ES300_RS08015 Protein ID WP_000961810.1
Coordinates 1599204..1599656 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES300_RS07990 (ES300_08410) 1594242..1596485 - 2244 WP_001094321.1 S8 family serine peptidase -
ES300_RS07995 (ES300_08415) 1596487..1597521 - 1035 WP_000747915.1 ATP-binding protein -
ES300_RS08000 (ES300_08420) 1597631..1597795 - 165 WP_000421870.1 hypothetical protein -
ES300_RS08005 (ES300_08425) 1597845..1598387 - 543 WP_000891119.1 hypothetical protein -
ES300_RS08010 (ES300_08430) 1598443..1598913 - 471 WP_000257102.1 DUF3013 family protein -
ES300_RS08015 (ES300_08435) 1599204..1599656 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ES300_RS08020 (ES300_08440) 1599693..1599872 - 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
ES300_RS08025 (ES300_08445) 1600009..1600188 - 180 WP_001048906.1 hypothetical protein -
ES300_RS08030 (ES300_08455) 1600392..1600592 - 201 WP_000818077.1 hypothetical protein -
ES300_RS08035 (ES300_08465) 1600862..1602133 + 1272 WP_001113214.1 replication-associated recombination protein A -
ES300_RS08045 (ES300_08475) 1602680..1603999 - 1320 WP_000502537.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T120858 WP_001132282.1 NZ_CP038251:c1599872-1599693 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T120858 NZ_CP038251:c1599872-1599693 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACTTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT120858 WP_000961810.1 NZ_CP038251:c1599656-1599204 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT120858 NZ_CP038251:c1599656-1599204 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATAAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References