120857

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1125817..1126315 Replicon chromosome
Accession NZ_CP038251
Organism Streptococcus pneumoniae strain TVO_1901944

Toxin (Protein)


Gene name relE Uniprot ID C1CEI0
Locus tag ES300_RS05590 Protein ID WP_001823540.1
Coordinates 1125817..1126071 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag ES300_RS05595 Protein ID WP_000208080.1
Coordinates 1126073..1126315 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES300_RS05575 (ES300_05865) 1121078..1123546 - 2469 WP_001152992.1 DNA gyrase subunit A -
ES300_RS05580 (ES300_05870) 1123740..1124726 + 987 WP_000204727.1 L-lactate dehydrogenase -
ES300_RS05585 (ES300_05875) 1125075..1125770 - 696 WP_000731163.1 potassium channel family protein -
ES300_RS05590 (ES300_05880) 1125817..1126071 - 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ES300_RS05595 (ES300_05885) 1126073..1126315 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
ES300_RS05600 (ES300_05890) 1126406..1127215 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
ES300_RS05605 (ES300_05895) 1127217..1128566 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
ES300_RS05610 (ES300_05900) 1128559..1129263 - 705 WP_000722076.1 response regulator YycF -
ES300_RS05615 (ES300_05905) 1129318..1130493 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -
ES300_RS10675 1130590..1130715 + 126 WP_001818232.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10040.76 Da        Isoelectric Point: 10.9371

>T120857 WP_001823540.1 NZ_CP038251:c1126071-1125817 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T120857 NZ_CP038251:c1126071-1125817 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGTCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT120857 WP_000208080.1 NZ_CP038251:c1126315-1126073 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT120857 NZ_CP038251:c1126315-1126073 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C1CEI0

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References