120855

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-doc
Location 28703..29286 Replicon plasmid p1GD01
Accession NZ_CP038243
Organism Staphylococcus warneri strain GD01

Toxin (Protein)


Gene name pemK Uniprot ID C5QR44
Locus tag EOJ31_RS12260 Protein ID WP_002442047.1
Coordinates 28703..29041 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID C5QR43
Locus tag EOJ31_RS12265 Protein ID WP_002442045.1
Coordinates 29038..29286 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EOJ31_RS12230 24236..24328 - 93 WP_001791613.1 type I toxin-antitoxin system Fst family toxin -
EOJ31_RS12235 24489..24836 - 348 WP_002452612.1 metalloregulator ArsR/SmtB family transcription factor -
EOJ31_RS12240 24855..25472 - 618 WP_186335213.1 CadD family cadmium resistance transporter -
EOJ31_RS12245 25670..26206 + 537 WP_145376084.1 hypothetical protein -
EOJ31_RS12250 27084..27731 - 648 Protein_31 protein rep -
EOJ31_RS12255 27791..28465 - 675 Protein_32 IS6 family transposase -
EOJ31_RS12260 28703..29041 - 339 WP_002442047.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EOJ31_RS12265 29038..29286 - 249 WP_002442045.1 hypothetical protein Antitoxin
EOJ31_RS12270 29635..30000 - 366 Protein_35 hypothetical protein -
EOJ31_RS12275 30059..30733 + 675 Protein_36 IS6 family transposase -
EOJ31_RS12280 30944..31300 + 357 WP_145376078.1 hypothetical protein -
EOJ31_RS12285 32028..32246 + 219 WP_000153199.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..32338 32338
- inside IScluster/Tn - - 28322..30202 1880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13134.25 Da        Isoelectric Point: 9.6404

>T120855 WP_002442047.1 NZ_CP038243:c29041-28703 [Staphylococcus warneri]
MSIKQFDIYYIDLDPTRGREKQKIRPCLIVNNNMTIKGTDFVWVLPITNREKRYPLDIEVKTKKGLVTGVIDTLQIRALD
LNEREHNYKDELQDNLKNVVLQAIKTYLKPSS

Download         Length: 339 bp

>T120855 NZ_CP038243:c29041-28703 [Staphylococcus warneri]
ATGAGTATCAAACAGTTTGATATATACTATATTGACCTAGACCCCACTCGAGGTCGTGAAAAACAAAAAATTAGACCATG
CTTAATCGTGAATAACAATATGACCATTAAAGGAACAGATTTTGTTTGGGTATTACCAATTACAAATCGTGAAAAACGTT
ATCCATTAGATATCGAAGTGAAAACTAAAAAAGGATTAGTCACAGGTGTTATAGACACGCTTCAGATACGCGCATTAGAC
CTTAATGAACGTGAACATAACTATAAAGATGAATTACAAGACAACTTAAAAAACGTCGTCTTACAAGCAATAAAGACGTA
TTTAAAACCATCATCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9210.33 Da        Isoelectric Point: 4.5463

>AT120855 WP_002442045.1 NZ_CP038243:c29286-29038 [Staphylococcus warneri]
MIKTSERIFKSGNSKALSLSKQTIQLADFEVGDKVEVSEINGGLFIKKKEESIEDEITNFFKNGGKYTEPEFDFGESVGR
EI

Download         Length: 249 bp

>AT120855 NZ_CP038243:c29286-29038 [Staphylococcus warneri]
ATGATTAAAACATCTGAACGCATTTTTAAAAGTGGAAACAGCAAAGCACTCAGTTTAAGCAAACAAACAATCCAGTTAGC
TGATTTTGAGGTGGGAGATAAGGTTGAAGTATCTGAAATCAATGGTGGTTTATTTATCAAAAAGAAAGAAGAATCGATTG
AAGATGAAATCACAAATTTTTTCAAAAATGGCGGTAAATACACCGAGCCAGAATTTGATTTTGGAGAGAGTGTAGGTCGT
GAAATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A269XML6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J6P0H1

References