Detailed information of TA system TA120854

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1950330..1950792
• Replicon: chromosome
• Accession: NZ_CP038242
• Organism: Staphylococcus warneri strain GD01

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: A0A2V3ZEQ2
• Locus tag: EOJ31_RS09510
• Protein ID: WP_002465948.1
• Coordinates: 1950607..1950792 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: A0A364UQZ8
• Locus tag: EOJ31_RS09505
• Protein ID: WP_015365250.1
• Coordinates: 1950330..1950587 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EOJ31_RS09465	1945538..1945861	+	324	WP_015365247.1	thioredoxin family protein	-
EOJ31_RS09470	1945973..1946512	-	540	WP_002465937.1	nitroreductase	-
EOJ31_RS09475	1946590..1947306	-	717	WP_019235836.1	type I 3-dehydroquinate dehydratase	-
EOJ31_RS09480	1947482..1947904	+	423	WP_002450862.1	organic hydroperoxide resistance protein	-
EOJ31_RS09485	1948182..1948676	+	495	WP_002465942.1	GNAT family N-acetyltransferase	-
EOJ31_RS09490	1948809..1949399	-	591	WP_002465945.1	histidine phosphatase family protein	-
EOJ31_RS09495	1949608..1949841	+	234	WP_002450865.1	hypothetical protein	-
EOJ31_RS09500	1949833..1950036	-	204	WP_015365249.1	sterile alpha motif-like domain-containing protein	-
EOJ31_RS09505	1950330..1950587	+	258	WP_015365250.1	hypothetical protein	Antitoxin
EOJ31_RS09510	1950607..1950792	+	186	WP_002465948.1	hypothetical protein	Toxin
EOJ31_RS09515	1950893..1951474	+	582	WP_015365251.1	hypothetical protein	-
EOJ31_RS09520	1951534..1951767	-	234	WP_002450870.1	hypothetical protein	-
EOJ31_RS09525	1952032..1952784	+	753	WP_002465946.1	poly-gamma-glutamate hydrolase family protein	-
EOJ31_RS09530	1952875..1953159	+	285	WP_002465939.1	hypothetical protein	-
EOJ31_RS09535	1953237..1953452	+	216	WP_002465949.1	hypothetical protein	-
EOJ31_RS09540	1953917..1954156	+	240	WP_002465943.1	hypothetical protein	-
EOJ31_RS09545	1954385..1954618	+	234	WP_015365252.1	hypothetical protein	-
EOJ31_RS09550	1954793..1954993	-	201	WP_002450876.1	cold-shock protein	-
EOJ31_RS09555	1955314..1955679	-	366	WP_002466279.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (6-58)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6977.68 Da
• Isoelectric Point: 10.1605

>T120854 WP_002465948.1 NZ_CP038242:1950607-1950792 [Staphylococcus warneri]
MSLHFTILFWLSLIFIVAGAIILAIMLKTKKESKKESYLGFTIVFFIFGLAMLIYTLLFGL

Nucleotide

• Length: 186 bp

>T120854 NZ_CP038242:1950607-1950792 [Staphylococcus warneri]
ATGAGCTTGCATTTTACAATTCTTTTTTGGCTTTCACTTATATTTATCGTAGCTGGTGCGATTATTCTAGCTATCATGCT
TAAAACTAAAAAAGAATCTAAGAAAGAATCTTATCTTGGTTTCACCATTGTATTCTTCATTTTTGGATTAGCTATGTTGA
TATATACATTGTTATTCGGACTCTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9908.17 Da
• Isoelectric Point: 4.5910

>AT120854 WP_015365250.1 NZ_CP038242:1950330-1950587 [Staphylococcus warneri]
MKLYIIHAINIILTILFIIFNVIITYNANLDDTLWLVPGLIVCGLIMMISFAIAITKKDLLSEVLFFINIILTLYYIYPI
FYDFL

Nucleotide

• Length: 258 bp

>AT120854 NZ_CP038242:1950330-1950587 [Staphylococcus warneri]
ATGAAACTATACATTATACATGCAATCAATATTATTTTAACGATATTATTTATTATTTTTAATGTAATTATTACTTATAA
TGCAAACCTAGACGATACCTTATGGTTAGTGCCTGGATTAATTGTATGCGGTTTGATTATGATGATTAGTTTTGCTATTG
CTATAACTAAAAAGGACTTGTTAAGTGAAGTTCTTTTCTTTATTAATATTATTCTTACACTGTACTACATTTATCCAATT
TTTTATGATTTTCTTTAA

Structures

Toxin

• AlphaFold DB: A0A2V3ZEQ2

Antitoxin

• AlphaFold DB: A0A364UQZ8