Detailed information of TA system TA120850

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 990301..991107
• Replicon: chromosome
• Accession: NZ_CP038242
• Organism: Staphylococcus warneri strain GD01

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: A0A364UNB4
• Locus tag: EOJ31_RS04920
• Protein ID: WP_002466824.1
• Coordinates: 990928..991107 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A364UN40
• Locus tag: EOJ31_RS04915
• Protein ID: WP_015364870.1
• Coordinates: 990301..990900 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EOJ31_RS04895	986102..987562	+	1461	WP_002466813.1	ABC transporter substrate-binding protein/permease	-
EOJ31_RS04900	987555..988277	+	723	WP_002466809.1	amino acid ABC transporter ATP-binding protein	-
EOJ31_RS04905	988520..989650	+	1131	WP_002466804.1	tRNA epoxyqueuosine(34) reductase QueG	-
EOJ31_RS04910	989651..990121	+	471	WP_002466802.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
EOJ31_RS04915	990301..990900	+	600	WP_015364870.1	glucosamine-6-phosphate isomerase	Antitoxin
EOJ31_RS04920	990928..991107	+	180	WP_002466824.1	hypothetical protein	Toxin
EOJ31_RS04925	991250..991642	+	393	WP_015364871.1	hypothetical protein	-
EOJ31_RS04930	991797..993182	+	1386	WP_002466811.1	class II fumarate hydratase	-
EOJ31_RS04935	993243..994073	-	831	WP_189723572.1	RluA family pseudouridine synthase	-
EOJ31_RS04940	994251..995363	+	1113	WP_002466816.1	GAF domain-containing sensor histidine kinase	-
EOJ31_RS04945	995384..996007	+	624	WP_002466822.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6901.22 Da
• Isoelectric Point: 3.8441

>T120850 WP_002466824.1 NZ_CP038242:990928-991107 [Staphylococcus warneri]
MTQNKDSKTNYHEEENAMVTDLDDLKDLGKEMEQISEENDEEKLNQSHDSDVRSDLDQD

Nucleotide

• Length: 180 bp

>T120850 NZ_CP038242:990928-991107 [Staphylococcus warneri]
ATGACTCAAAATAAAGATTCTAAAACGAATTACCACGAAGAAGAAAATGCAATGGTAACCGATTTAGATGATTTAAAAGA
CTTAGGAAAAGAAATGGAACAAATTTCTGAAGAAAATGATGAAGAAAAATTAAATCAATCTCATGATTCAGATGTTCGTT
CTGATTTAGATCAAGATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22602.48 Da
• Isoelectric Point: 4.8492

>AT120850 WP_015364870.1 NZ_CP038242:990301-990900 [Staphylococcus warneri]
MAMNFKVFEDKQRVAEYTADILRKQFNNNPMTIAGVHLTKDHAPVLDELKKNVDLHAVDFSQINILDYDENQSYYEALGV
PQSQIYSLSYNQDANDFISDKIKTKENKGKLVLQVVSIDENGNLDVSVRQGLLEAREIFLVVTGSNKREVVEKLYNENGK
SNFEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT120850 NZ_CP038242:990301-990900 [Staphylococcus warneri]
ATGGCAATGAACTTTAAAGTATTTGAAGATAAACAAAGAGTAGCTGAATATACAGCAGACATTTTGAGAAAACAATTTAA
TAACAACCCAATGACAATCGCAGGTGTTCATTTAACAAAAGATCATGCACCTGTATTAGATGAATTAAAAAAGAATGTTG
ATTTACATGCAGTTGATTTCAGTCAAATTAATATTTTAGATTATGATGAAAATCAATCATATTATGAAGCGTTAGGTGTA
CCACAAAGCCAAATTTATTCATTATCATACAACCAAGATGCTAATGACTTTATTTCAGATAAAATTAAAACAAAGGAAAA
TAAAGGTAAATTAGTCTTACAAGTTGTTTCAATTGATGAAAATGGTAATTTAGATGTAAGTGTAAGACAAGGGTTATTAG
AAGCACGCGAAATCTTCTTAGTTGTTACTGGTAGTAATAAACGTGAAGTAGTCGAAAAATTATATAACGAAAATGGAAAA
TCTAATTTTGAACCTGCAGACTTAAAAGCGCACCGTATGGTTAACGTTATTTTAGATAAAGAAGCAGCAGCTGGATTACC
TGAAGACGTGAAAGAATACTTCACAGCTCGCTTTGCATAA

Structures

Toxin

• AlphaFold DB: A0A364UNB4

Antitoxin

• AlphaFold DB: A0A364UN40