120848

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 840834..841344 Replicon chromosome
Accession NZ_CP038242
Organism Staphylococcus warneri strain GD01

Toxin (Protein)


Gene name TsdT Uniprot ID A0A364UNH7
Locus tag EOJ31_RS04065 Protein ID WP_002466743.1
Coordinates 841138..841344 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A364UNN3
Locus tag EOJ31_RS04060 Protein ID WP_002466760.1
Coordinates 840834..841127 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EOJ31_RS04035 835960..836751 + 792 WP_002466779.1 hydroxyethylthiazole kinase -
EOJ31_RS04040 836752..837393 + 642 WP_015364827.1 thiamine phosphate synthase -
EOJ31_RS04045 837482..838351 + 870 WP_002466746.1 membrane protein insertase YidC -
EOJ31_RS04050 838389..839033 - 645 WP_002466781.1 HD domain-containing protein -
EOJ31_RS04055 839161..840645 - 1485 WP_002466786.1 cardiolipin synthase -
EOJ31_RS04060 840834..841127 + 294 WP_002466760.1 copper-sensing transcriptional repressor CsoR Antitoxin
EOJ31_RS04065 841138..841344 + 207 WP_002466743.1 heavy-metal-associated domain-containing protein Toxin
EOJ31_RS04070 841483..841620 + 138 WP_002466770.1 hypothetical protein -
EOJ31_RS04075 841760..842950 - 1191 WP_189723557.1 rod shape-determining protein RodA -
EOJ31_RS04080 843308..844378 + 1071 WP_002466764.1 D-alanine--D-alanine ligase -
EOJ31_RS04085 844394..845755 + 1362 WP_002466757.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7670.62 Da        Isoelectric Point: 3.8601

>T120848 WP_002466743.1 NZ_CP038242:841138-841344 [Staphylococcus warneri]
VQQKIVYTAGIETQEQSEAIKNLLTEMIGVYQVDIDINSGNITIEFETPANLNSIEKEIYDAGYKVLY

Download         Length: 207 bp

>T120848 NZ_CP038242:841138-841344 [Staphylococcus warneri]
GTGCAACAAAAAATTGTATATACTGCTGGAATAGAAACACAAGAACAATCTGAAGCTATAAAAAATCTTTTAACTGAAAT
GATAGGTGTATATCAAGTTGATATTGATATCAATTCTGGAAACATAACAATTGAATTTGAGACACCTGCGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGCTGGATATAAAGTGCTCTATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11199.74 Da        Isoelectric Point: 6.3263

>AT120848 WP_002466760.1 NZ_CP038242:840834-841127 [Staphylococcus warneri]
VTEQDHAHHSEQIKVNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIADKVNQGHQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT120848 NZ_CP038242:840834-841127 [Staphylococcus warneri]
GTGACAGAACAAGATCATGCACATCACTCTGAACAAATTAAAGTCAATTTAAAATCGAGATTAAACCGAATTGAAGGTCA
AGTTAGAGCTATTAATCGAATGATAGAAGAGGATGTTTATTGCGATGATGTGTTAACTCAAATTAGAGCTACACGTTCTG
CATTAAATAGTGTAGCTACTAAATTATTAGAACAACATATGAAAAGTTGTATAGCAGATAAAGTAAATCAAGGTCATCAA
GAAGAAGCAATGGAGGAACTACTCGTTACGTTTCAAAAATTAATGAAAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364UNH7

Antitoxin

Source ID Structure
AlphaFold DB A0A364UNN3

References