Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-hicB/YafQ(toxin)
Location 1411050..1411742 Replicon chromosome
Accession NZ_CP038241
Organism Allofrancisella inopinata strain SYSU YG23

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag E4K63_RS06460 Protein ID WP_133942361.1
Coordinates 1411464..1411742 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag E4K63_RS06455 Protein ID WP_133942362.1
Coordinates 1411050..1411382 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4K63_RS06430 1406186..1407319 - 1134 WP_133942528.1 capsule biosynthesis protein -
E4K63_RS06435 1407800..1408183 + 384 WP_133942529.1 hypothetical protein -
E4K63_RS06440 1408470..1408886 + 417 WP_133942530.1 hypothetical protein -
E4K63_RS06445 1409173..1409502 + 330 WP_133942531.1 hypothetical protein -
E4K63_RS06450 1409575..1410805 - 1231 Protein_1247 IS256 family transposase -
E4K63_RS06455 1411050..1411382 - 333 WP_133942362.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E4K63_RS06460 1411464..1411742 - 279 WP_133942361.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
E4K63_RS06465 1411736..1411978 - 243 WP_133942360.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
E4K63_RS06470 1412207..1413277 - 1071 WP_133942364.1 capsule polysaccharide transporter -
E4K63_RS06475 1413333..1414277 - 945 WP_179965698.1 hypothetical protein -
E4K63_RS06480 1414378..1415607 - 1230 WP_133942358.1 hypothetical protein -
E4K63_RS06485 1415604..1416221 - 618 WP_133942357.1 HAD family hydrolase -
E4K63_RS06490 1416218..1416706 - 489 WP_166666916.1 YhcH/YjgK/YiaL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10963.02 Da        Isoelectric Point: 10.1214

>T120844 WP_133942361.1 NZ_CP038241:c1411742-1411464 [Allofrancisella inopinata]
VLEVFETKRFLKSYKKIKHKKKILEELQKAIKFLITQQEIPKKYKDHELKGKFSGIRELHLGYDDLLLYFVINEEKKLVL
VDIGTHAHTLNI

Download         Length: 279 bp

>T120844 NZ_CP038241:c1411742-1411464 [Allofrancisella inopinata]
GTGTTAGAAGTCTTTGAAACTAAGAGATTTCTTAAGAGTTATAAAAAGATAAAGCACAAAAAGAAAATCTTAGAAGAATT
ACAAAAAGCGATTAAATTTTTAATAACACAACAAGAAATACCTAAAAAATACAAAGATCATGAGCTTAAAGGAAAATTCT
CTGGCATTAGAGAACTACATTTAGGATACGATGATTTACTCCTATATTTTGTAATTAATGAAGAAAAGAAATTAGTATTA
GTAGATATAGGAACTCACGCACATACATTAAATATCTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12429.91 Da        Isoelectric Point: 4.7414

>AT120844 WP_133942362.1 NZ_CP038241:c1411382-1411050 [Allofrancisella inopinata]
MNNLIKHKGYYGSVEFDEESMVFYGQIQFIRSLISYEAENAKELVDSFHSAVDEYLEDCKERGVEPEKAFRGTLNVRLGT
DLHEKVAIAASNMGTSINDFIKQSLNKSTA

Download         Length: 333 bp

>AT120844 NZ_CP038241:c1411382-1411050 [Allofrancisella inopinata]
ATGAATAACCTAATAAAGCATAAAGGATATTATGGCTCTGTTGAGTTTGATGAAGAAAGCATGGTTTTTTATGGTCAAAT
TCAATTCATTAGAAGCCTTATATCTTATGAGGCTGAAAATGCTAAAGAGTTAGTAGATAGCTTTCATAGTGCTGTAGATG
AGTATCTAGAAGATTGTAAAGAAAGAGGAGTTGAGCCTGAAAAAGCTTTCAGGGGTACTTTAAATGTTAGGCTTGGTACT
GATCTGCATGAAAAAGTAGCTATAGCAGCTAGTAATATGGGTACTAGTATTAATGATTTTATCAAACAATCTCTTAATAA
AAGTACTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References