Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 492058..492683 Replicon chromosome
Accession NZ_CP038241
Organism Allofrancisella inopinata strain SYSU YG23

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E4K63_RS02285 Protein ID WP_133942559.1
Coordinates 492285..492683 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E4K63_RS02280 Protein ID WP_133942558.1
Coordinates 492058..492288 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4K63_RS02250 487666..487920 + 255 WP_035719788.1 DUF2442 domain-containing protein -
E4K63_RS02255 487945..488538 + 594 WP_179965680.1 recombinase family protein -
E4K63_RS08125 488806..489357 + 552 WP_208318271.1 SEC-C domain-containing protein -
E4K63_RS02265 489658..490200 + 543 WP_133942555.1 hypothetical protein -
E4K63_RS02270 490257..491315 + 1059 WP_179965681.1 transposase -
E4K63_RS02275 491321..491956 + 636 WP_179965682.1 hypothetical protein -
E4K63_RS02280 492058..492288 + 231 WP_133942558.1 antitoxin Antitoxin
E4K63_RS02285 492285..492683 + 399 WP_133942559.1 PIN domain-containing protein Toxin
E4K63_RS02290 493031..494245 + 1215 WP_179965683.1 lipase family protein -
E4K63_RS02295 494235..494774 + 540 WP_133942391.1 hypothetical protein -
E4K63_RS02300 495052..495699 + 648 WP_133942392.1 hypothetical protein -
E4K63_RS02305 495700..496572 + 873 WP_208318267.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15131.53 Da        Isoelectric Point: 7.3566

>T120843 WP_133942559.1 NZ_CP038241:492285-492683 [Allofrancisella inopinata]
MKVMLDTNICIYIINEKPKSVFDHFRKYEIGEIGISSIVYAELLHGAFKSQRINQNLTALHNFTTALQIRDFDKTAAIEY
GKIRSDLEKSGRMIGANDLFIAAHVKSLNIPLATNNTKEFERIEDLMLLNWI

Download         Length: 399 bp

>T120843 NZ_CP038241:492285-492683 [Allofrancisella inopinata]
ATGAAGGTTATGCTAGATACTAATATATGTATATACATTATAAATGAGAAACCAAAATCAGTATTTGATCACTTTCGTAA
ATATGAAATAGGTGAGATTGGTATTTCATCAATAGTGTATGCCGAGTTATTGCATGGTGCATTTAAAAGTCAAAGAATAA
ACCAAAACCTTACTGCATTACATAATTTCACAACTGCATTACAGATTAGAGACTTTGATAAGACTGCAGCCATTGAGTAT
GGTAAAATAAGATCTGACTTAGAGAAATCAGGTAGAATGATTGGGGCAAATGATTTATTTATTGCGGCTCATGTTAAATC
TTTGAACATACCATTAGCAACTAATAACACTAAAGAGTTTGAAAGAATTGAGGATTTAATGTTATTAAATTGGATATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8970.24 Da        Isoelectric Point: 4.6411

>AT120843 WP_133942558.1 NZ_CP038241:492058-492288 [Allofrancisella inopinata]
MITKLFMNGNSQAVRIPKEMQFKVKEVEINRIGNSVIITELPESWDKVFQSLDEFSEDFFKSGREQPELETREVFK

Download         Length: 231 bp

>AT120843 NZ_CP038241:492058-492288 [Allofrancisella inopinata]
ATGATTACTAAGCTTTTTATGAACGGAAATAGTCAAGCAGTCAGAATTCCAAAAGAAATGCAGTTTAAAGTCAAAGAAGT
AGAAATTAATAGAATAGGTAACTCTGTAATAATTACTGAATTACCAGAAAGCTGGGATAAAGTGTTTCAATCATTAGACG
AATTTAGTGAGGATTTTTTTAAAAGTGGCAGAGAGCAACCGGAATTAGAAACTAGAGAAGTTTTCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References