Detailed information of TA system TA120842

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 212351..212948
• Replicon: chromosome
• Accession: NZ_CP038231
• Organism: Swingsia sp. F3b2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: E3E12_RS00905
• Protein ID: WP_141442635.1
• Coordinates: 212769..212948 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: E3E12_RS00900
• Protein ID: WP_141442634.1
• Coordinates: 212351..212758 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3E12_RS00885	208274..208765	-	492	WP_141442632.1	MucR family transcriptional regulator	-
E3E12_RS00890	209247..211802	+	2556	WP_141442633.1	FUSC family protein	-
E3E12_RS00900	212351..212758	-	408	WP_141442634.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
E3E12_RS00905	212769..212948	-	180	WP_141442635.1	type II toxin-antitoxin system HicA family toxin	Toxin
E3E12_RS00910	213555..214961	-	1407	WP_141442636.1	virulence-associated E family protein	-
E3E12_RS00915	214958..215506	-	549	WP_141442637.1	hypothetical protein	-
E3E12_RS00920	216248..216469	-	222	WP_141442638.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-124)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6562.87 Da
• Isoelectric Point: 12.0707

>T120842 WP_141442635.1 NZ_CP038231:c212948-212769 [Swingsia sp. F3b2]
MKSADLIREMQQAGWMLVRVRGSHHVFRHPAKPGSVIVPHPKKDLGKGLVKAIRKQAGL

Nucleotide

• Length: 180 bp

>T120842 NZ_CP038231:c212948-212769 [Swingsia sp. F3b2]
ATGAAAAGCGCTGACCTTATCCGCGAGATGCAGCAAGCGGGCTGGATGCTGGTGCGTGTGAGGGGTTCTCACCATGTGTT
CCGTCATCCAGCCAAGCCTGGCAGCGTGATAGTCCCCCATCCCAAAAAGGATTTGGGCAAAGGACTGGTTAAGGCCATCC
GCAAACAAGCAGGCCTTTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14180.01 Da
• Isoelectric Point: 4.3101

>AT120842 WP_141442634.1 NZ_CP038231:c212758-212351 [Swingsia sp. F3b2]
MRYPVMIEAGTDDTAFGAVVPDLPGCFSAGDTLDEALSNVEEAAQLWVETALDAGEEVPAPSTLAAHQKAYPGWLVGFVT
LDPALLDNRIERVNISLPRRVLGRLDALAAARHQSRSATIAALALQADAGTAGRV

Nucleotide

• Length: 408 bp

>AT120842 NZ_CP038231:c212758-212351 [Swingsia sp. F3b2]
ATGCGTTATCCCGTCATGATTGAAGCTGGCACAGACGACACGGCCTTTGGTGCGGTGGTGCCAGATCTGCCCGGCTGCTT
CTCTGCTGGTGACACCCTGGACGAGGCTTTGAGCAATGTTGAGGAGGCAGCCCAGCTGTGGGTGGAAACGGCTTTGGATG
CAGGCGAAGAGGTGCCTGCCCCAAGCACCTTGGCCGCCCACCAGAAAGCTTATCCAGGGTGGTTAGTGGGCTTTGTCACA
CTTGACCCAGCGTTGCTGGACAACCGCATAGAGCGTGTGAACATTTCCCTGCCGCGCCGCGTTCTGGGGCGGTTGGATGC
CCTGGCCGCTGCCCGCCATCAAAGCCGCTCAGCCACCATTGCCGCCTTGGCCCTGCAAGCGGATGCTGGCACGGCTGGCA
GGGTGTGA