Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 824376..824853 Replicon chromosome
Accession NZ_CP038229
Organism Staphylococcus aureus strain MJ163

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E4J95_RS03860 Protein ID WP_000052076.1
Coordinates 824376..824564 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E4J95_RS03865 Protein ID WP_001059690.1
Coordinates 824593..824853 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4J95_RS03830 820417..820887 + 471 WP_000824472.1 hypothetical protein -
E4J95_RS03835 821228..821914 + 687 WP_001566557.1 thermonuclease family protein -
E4J95_RS03840 822271..822471 + 201 WP_001059082.1 cold-shock protein -
E4J95_RS03845 822967..823185 - 219 WP_000005886.1 hypothetical protein -
E4J95_RS03850 823247..823531 - 285 WP_001004401.1 hypothetical protein -
E4J95_RS03855 823619..824188 - 570 WP_045178121.1 orthopoxovirus protein, PF05708 family -
E4J95_RS03860 824376..824564 - 189 WP_000052076.1 hypothetical protein Toxin
E4J95_RS03865 824593..824853 - 261 WP_001059690.1 hypothetical protein Antitoxin
E4J95_RS03870 825194..825397 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E4J95_RS03875 825394..825630 - 237 WP_000368687.1 hypothetical protein -
E4J95_RS03880 825855..826436 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
E4J95_RS03885 826509..827126 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
E4J95_RS03890 827281..827775 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
E4J95_RS03895 828174..828596 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
E4J95_RS03900 828744..829460 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T120830 WP_000052076.1 NZ_CP038229:c824564-824376 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T120830 NZ_CP038229:c824564-824376 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT120830 WP_001059690.1 NZ_CP038229:c824853-824593 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT120830 NZ_CP038229:c824853-824593 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References