Detailed information of TA system TA120815

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 1540310..1540980
• Replicon: chromosome
• Accession: NZ_CP038213
• Organism: Ornithinimicrobium flavum strain CPCC 203535

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: E3Z34_RS07125
• Protein ID: WP_134773049.1
• Coordinates: 1540310..1540705 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: E3Z34_RS07130
• Protein ID: WP_134773050.1
• Coordinates: 1540705..1540980 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3Z34_RS07095	1535318..1536202	+	885	WP_134773043.1	catechol 1,2-dioxygenase	-
E3Z34_RS07100	1536232..1536513	+	282	WP_134773044.1	muconolactone delta-isomerase	-
E3Z34_RS07105	1536530..1537363	+	834	WP_134773045.1	alpha/beta hydrolase	-
E3Z34_RS07110	1537399..1537632	+	234	WP_134773046.1	hypothetical protein	-
E3Z34_RS07115	1537629..1538063	+	435	WP_134773047.1	PIN domain-containing protein	-
E3Z34_RS07120	1538170..1540227	-	2058	WP_134773048.1	AarF/ABC1/UbiB kinase family protein	-
E3Z34_RS07125	1540310..1540705	-	396	WP_134773049.1	type II toxin-antitoxin system VapC family toxin	Toxin
E3Z34_RS07130	1540705..1540980	-	276	WP_134773050.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
E3Z34_RS07135	1541091..1541717	+	627	WP_134773051.1	hypothetical protein	-
E3Z34_RS07140	1541711..1543351	-	1641	WP_134773052.1	thiamine pyrophosphate-binding protein	-
E3Z34_RS07145	1543366..1544136	-	771	WP_134773053.1	cyclase family protein	-
E3Z34_RS07150	1544220..1545698	+	1479	WP_134773054.1	cryptochrome/photolyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-119)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-43)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14519.69 Da
• Isoelectric Point: 4.6307

>T120815 WP_134773049.1 NZ_CP038213:c1540705-1540310 [Ornithinimicrobium flavum]
MGYYLDTSALVKLVAPEPGSDELRRWIEARSDALVTSDLARTELFRAVRRVRPDQAPLARQVMDTLTVLRMDTGVFEEAA
RLDPPGLRSLDALHLAAALMLEDDLQGVVTYDERLAEATRLVGFLVLAPGR

Nucleotide

• Length: 396 bp

>T120815 NZ_CP038213:c1540705-1540310 [Ornithinimicrobium flavum]
ATGGGCTACTACCTGGACACGTCCGCCCTGGTGAAACTGGTCGCACCTGAGCCGGGGTCAGACGAGCTCCGCCGATGGAT
CGAGGCACGGTCGGACGCGTTGGTGACCTCCGATCTCGCCCGGACCGAGCTCTTCCGAGCCGTACGCCGGGTGAGGCCGG
ATCAGGCGCCGTTGGCGCGGCAGGTGATGGACACGCTCACGGTGTTGCGGATGGACACCGGCGTCTTCGAGGAGGCGGCC
CGCCTGGACCCACCCGGGCTACGCTCCCTCGACGCCCTGCACCTGGCCGCCGCGCTCATGCTCGAGGACGACCTCCAGGG
CGTGGTGACGTATGACGAACGTCTCGCGGAGGCCACGCGGCTGGTCGGGTTCCTCGTCCTGGCGCCGGGGCGCTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9573.96 Da
• Isoelectric Point: 11.5411

>AT120815 WP_134773050.1 NZ_CP038213:c1540980-1540705 [Ornithinimicrobium flavum]
MAERTIGIRELKQNASAAVARAAAGEALVVTDHGRPVARLVPLGVSRTSALVIAGRARPPRLPLADLPRPQGAPSTALSE
ALGQDREDQRY

Nucleotide

• Length: 276 bp

>AT120815 NZ_CP038213:c1540980-1540705 [Ornithinimicrobium flavum]
ATGGCAGAACGCACGATCGGCATTCGTGAGCTGAAGCAGAACGCCTCGGCGGCGGTGGCCCGGGCCGCAGCCGGTGAGGC
ATTGGTGGTCACCGATCACGGCCGTCCGGTCGCACGACTGGTCCCCCTCGGTGTCAGCCGCACGTCCGCTCTCGTCATCG
CCGGGCGAGCCCGACCACCCCGACTCCCCCTGGCCGACCTCCCCCGGCCCCAGGGCGCACCGAGCACCGCACTGTCAGAG
GCTCTTGGCCAGGACCGCGAGGACCAGCGCTACTGA