Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 1540310..1540980 Replicon chromosome
Accession NZ_CP038213
Organism Ornithinimicrobium flavum strain CPCC 203535

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E3Z34_RS07125 Protein ID WP_134773049.1
Coordinates 1540310..1540705 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E3Z34_RS07130 Protein ID WP_134773050.1
Coordinates 1540705..1540980 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3Z34_RS07095 1535318..1536202 + 885 WP_134773043.1 catechol 1,2-dioxygenase -
E3Z34_RS07100 1536232..1536513 + 282 WP_134773044.1 muconolactone delta-isomerase -
E3Z34_RS07105 1536530..1537363 + 834 WP_134773045.1 alpha/beta hydrolase -
E3Z34_RS07110 1537399..1537632 + 234 WP_134773046.1 hypothetical protein -
E3Z34_RS07115 1537629..1538063 + 435 WP_134773047.1 PIN domain-containing protein -
E3Z34_RS07120 1538170..1540227 - 2058 WP_134773048.1 AarF/ABC1/UbiB kinase family protein -
E3Z34_RS07125 1540310..1540705 - 396 WP_134773049.1 type II toxin-antitoxin system VapC family toxin Toxin
E3Z34_RS07130 1540705..1540980 - 276 WP_134773050.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
E3Z34_RS07135 1541091..1541717 + 627 WP_134773051.1 hypothetical protein -
E3Z34_RS07140 1541711..1543351 - 1641 WP_134773052.1 thiamine pyrophosphate-binding protein -
E3Z34_RS07145 1543366..1544136 - 771 WP_134773053.1 cyclase family protein -
E3Z34_RS07150 1544220..1545698 + 1479 WP_134773054.1 cryptochrome/photolyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-43)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14519.69 Da        Isoelectric Point: 4.6307

>T120815 WP_134773049.1 NZ_CP038213:c1540705-1540310 [Ornithinimicrobium flavum]
MGYYLDTSALVKLVAPEPGSDELRRWIEARSDALVTSDLARTELFRAVRRVRPDQAPLARQVMDTLTVLRMDTGVFEEAA
RLDPPGLRSLDALHLAAALMLEDDLQGVVTYDERLAEATRLVGFLVLAPGR

Download         Length: 396 bp

>T120815 NZ_CP038213:c1540705-1540310 [Ornithinimicrobium flavum]
ATGGGCTACTACCTGGACACGTCCGCCCTGGTGAAACTGGTCGCACCTGAGCCGGGGTCAGACGAGCTCCGCCGATGGAT
CGAGGCACGGTCGGACGCGTTGGTGACCTCCGATCTCGCCCGGACCGAGCTCTTCCGAGCCGTACGCCGGGTGAGGCCGG
ATCAGGCGCCGTTGGCGCGGCAGGTGATGGACACGCTCACGGTGTTGCGGATGGACACCGGCGTCTTCGAGGAGGCGGCC
CGCCTGGACCCACCCGGGCTACGCTCCCTCGACGCCCTGCACCTGGCCGCCGCGCTCATGCTCGAGGACGACCTCCAGGG
CGTGGTGACGTATGACGAACGTCTCGCGGAGGCCACGCGGCTGGTCGGGTTCCTCGTCCTGGCGCCGGGGCGCTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9573.96 Da        Isoelectric Point: 11.5411

>AT120815 WP_134773050.1 NZ_CP038213:c1540980-1540705 [Ornithinimicrobium flavum]
MAERTIGIRELKQNASAAVARAAAGEALVVTDHGRPVARLVPLGVSRTSALVIAGRARPPRLPLADLPRPQGAPSTALSE
ALGQDREDQRY

Download         Length: 276 bp

>AT120815 NZ_CP038213:c1540980-1540705 [Ornithinimicrobium flavum]
ATGGCAGAACGCACGATCGGCATTCGTGAGCTGAAGCAGAACGCCTCGGCGGCGGTGGCCCGGGCCGCAGCCGGTGAGGC
ATTGGTGGTCACCGATCACGGCCGTCCGGTCGCACGACTGGTCCCCCTCGGTGTCAGCCGCACGTCCGCTCTCGTCATCG
CCGGGCGAGCCCGACCACCCCGACTCCCCCTGGCCGACCTCCCCCGGCCCCAGGGCGCACCGAGCACCGCACTGTCAGAG
GCTCTTGGCCAGGACCGCGAGGACCAGCGCTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References