Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-VapB
Location 1459647..1460218 Replicon chromosome
Accession NZ_CP038213
Organism Ornithinimicrobium flavum strain CPCC 203535

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E3Z34_RS06755 Protein ID WP_134772993.1
Coordinates 1459889..1460218 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag E3Z34_RS06750 Protein ID WP_134772992.1
Coordinates 1459647..1459886 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3Z34_RS06725 1454883..1456112 + 1230 WP_134772987.1 ATP-grasp domain-containing protein -
E3Z34_RS06730 1456117..1457331 + 1215 WP_134772988.1 ATP-grasp domain-containing protein -
E3Z34_RS06735 1457344..1457778 - 435 WP_134772989.1 universal stress protein -
E3Z34_RS06740 1457906..1458607 - 702 WP_134772990.1 hypothetical protein -
E3Z34_RS06745 1458777..1459550 + 774 WP_134772991.1 hypothetical protein -
E3Z34_RS06750 1459647..1459886 + 240 WP_134772992.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
E3Z34_RS06755 1459889..1460218 + 330 WP_134772993.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E3Z34_RS06760 1460227..1460853 - 627 WP_134772994.1 DUF4230 domain-containing protein -
E3Z34_RS06765 1460866..1461568 - 703 Protein_1345 GNAT family N-acetyltransferase -
E3Z34_RS18165 1461601..1462388 - 788 Protein_1346 NERD domain-containing protein -
E3Z34_RS06780 1462357..1462584 - 228 WP_134772997.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
E3Z34_RS06785 1462706..1462930 - 225 Protein_1348 hypothetical protein -
E3Z34_RS06790 1463153..1463707 - 555 WP_158288620.1 UvrD-helicase domain-containing protein -
E3Z34_RS06795 1463772..1465136 - 1365 WP_134772999.1 UvrD-helicase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(9-48)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11395.17 Da        Isoelectric Point: 6.9011

>T120814 WP_134772993.1 NZ_CP038213:1459889-1460218 [Ornithinimicrobium flavum]
VTLPARGELWWADLDEAGARPVVVVSRDAAIAGRRRALVAPCSTVIRGLPSEVLLEPGAEPVDRLCAAQADSLTDLPVAV
LTRRLGRVSDHAMRQLCTALNVAAGCTGA

Download         Length: 330 bp

>T120814 NZ_CP038213:1459889-1460218 [Ornithinimicrobium flavum]
GTGACACTTCCAGCCCGAGGCGAGCTCTGGTGGGCGGACCTGGACGAGGCCGGGGCGAGGCCCGTCGTCGTCGTGAGCCG
CGACGCGGCGATCGCCGGGCGTCGGCGCGCGCTGGTGGCACCGTGCAGCACGGTCATCCGGGGCCTCCCGAGCGAGGTGC
TGCTGGAGCCAGGTGCGGAGCCGGTGGATCGCCTCTGCGCGGCGCAGGCGGACTCGCTCACCGACCTCCCCGTAGCCGTC
CTGACTCGTCGGCTGGGGCGGGTCAGTGACCACGCGATGCGTCAGCTCTGCACTGCGCTCAACGTCGCGGCAGGGTGCAC
CGGCGCCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8704.74 Da        Isoelectric Point: 5.8041

>AT120814 WP_134772992.1 NZ_CP038213:1459647-1459886 [Ornithinimicrobium flavum]
MAKVRVSTTVDADLLARARKIFSGRTDASLVEAALEALLQQHRSAEIDAAYLRAYRDTPVDQRDDWGDLAAFADAAARR

Download         Length: 240 bp

>AT120814 NZ_CP038213:1459647-1459886 [Ornithinimicrobium flavum]
ATGGCAAAGGTGAGGGTGAGCACGACGGTCGACGCGGACCTTCTTGCGCGCGCGCGGAAGATCTTCTCCGGCCGGACCGA
CGCTTCATTGGTCGAGGCGGCCCTGGAGGCGCTCCTGCAGCAGCACCGGTCCGCCGAGATCGACGCGGCCTACCTGCGTG
CCTACCGGGACACCCCGGTGGACCAGCGCGACGACTGGGGTGACCTCGCGGCCTTCGCGGACGCCGCCGCCAGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References