Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 356919..357475 Replicon chromosome
Accession NZ_CP038213
Organism Ornithinimicrobium flavum strain CPCC 203535

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E3Z34_RS01680 Protein ID WP_022920828.1
Coordinates 356919..357239 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag E3Z34_RS01685 Protein ID WP_134772214.1
Coordinates 357242..357475 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3Z34_RS01640 352791..353435 - 645 WP_158288576.1 hypothetical protein -
E3Z34_RS01645 353538..354242 - 705 WP_158288577.1 class I SAM-dependent methyltransferase -
E3Z34_RS01650 354367..354609 - 243 WP_134772210.1 hypothetical protein -
E3Z34_RS01655 354628..354855 - 228 WP_202976999.1 hypothetical protein -
E3Z34_RS01660 354933..355862 + 930 WP_134772211.1 tyrosine-type recombinase/integrase -
E3Z34_RS01665 355947..356195 + 249 WP_122260808.1 ribbon-helix-helix protein, CopG family -
E3Z34_RS01670 356192..356434 + 243 WP_134772212.1 toxin -
E3Z34_RS01675 356522..356821 - 300 WP_134772213.1 hypothetical protein -
E3Z34_RS01680 356919..357239 - 321 WP_022920828.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E3Z34_RS01685 357242..357475 - 234 WP_134772214.1 hypothetical protein Antitoxin
E3Z34_RS01690 359144..359635 + 492 WP_134772215.1 transposase -
E3Z34_RS01695 360159..361466 - 1308 WP_134772184.1 ISL3 family transposase -
E3Z34_RS01700 361626..362198 + 573 WP_134772216.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 351351..371417 20066
- flank IS/Tn - - 360159..361466 1307


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-93)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11512.40 Da        Isoelectric Point: 5.6982

>T120813 WP_022920828.1 NZ_CP038213:c357239-356919 [Ornithinimicrobium flavum]
MREICLARLDKTRPVLVLTRDTARAVMTKVTVAPITSTVKGLSSEVPVGRANGLDHDSAVSIDNVLTIPADLLGRTLGFL
TPEQERHLARAIVLAYDLEVPLLEEP

Download         Length: 321 bp

>T120813 NZ_CP038213:c357239-356919 [Ornithinimicrobium flavum]
TTGCGCGAGATCTGCCTGGCGAGGCTGGACAAGACGCGCCCCGTCCTGGTGCTCACCCGTGACACTGCCCGCGCCGTGAT
GACCAAGGTGACCGTGGCTCCCATCACGTCGACTGTCAAGGGGTTGTCCAGCGAAGTACCGGTAGGCCGTGCTAACGGGC
TGGACCACGACAGTGCTGTCTCGATCGACAACGTCCTGACCATCCCCGCCGACCTCCTGGGCAGGACGCTGGGGTTCCTC
ACGCCCGAGCAGGAGCGCCACCTGGCAAGAGCCATCGTGCTGGCGTACGACCTCGAGGTGCCGCTGCTCGAAGAGCCGTG
A

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8320.45 Da        Isoelectric Point: 5.0176

>AT120813 WP_134772214.1 NZ_CP038213:c357475-357242 [Ornithinimicrobium flavum]
VTTQIAVRLPDEMVRFLDRSVASGKAASRAALVAAALEREMRVQAAQQDVQTLKKKGTADDLDELVAWSVAHATLDD

Download         Length: 234 bp

>AT120813 NZ_CP038213:c357475-357242 [Ornithinimicrobium flavum]
GTGACGACACAGATCGCGGTACGGCTCCCTGACGAGATGGTTCGCTTTCTGGACCGGAGCGTCGCCAGTGGCAAGGCTGC
CAGCCGAGCCGCGCTGGTGGCCGCGGCCCTGGAGCGCGAGATGCGCGTGCAGGCCGCGCAGCAGGACGTCCAGACCCTGA
AGAAGAAGGGCACGGCCGATGACCTCGACGAGCTCGTCGCCTGGTCCGTGGCCCACGCGACACTGGACGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References