120812

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 285612..286141 Replicon chromosome
Accession NZ_CP038213
Organism Ornithinimicrobium flavum strain CPCC 203535

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E3Z34_RS01320 Protein ID WP_134772163.1
Coordinates 285612..285938 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag E3Z34_RS01325 Protein ID WP_134772164.1
Coordinates 285935..286141 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3Z34_RS01300 280991..281944 - 954 WP_134772160.1 hypothetical protein -
E3Z34_RS01305 282010..282690 + 681 WP_134772161.1 GNAT family N-acetyltransferase -
E3Z34_RS01310 283347..283529 + 183 WP_134772162.1 hypothetical protein -
E3Z34_RS01315 283603..285160 - 1558 Protein_265 SulP family inorganic anion transporter -
E3Z34_RS01320 285612..285938 - 327 WP_134772163.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E3Z34_RS01325 285935..286141 - 207 WP_134772164.1 DUF3018 family protein Antitoxin
E3Z34_RS17575 286564..286761 - 198 WP_158288571.1 hypothetical protein -
E3Z34_RS01335 287038..287496 + 459 WP_134772166.1 GNAT family acetyltransferase -
E3Z34_RS01340 288169..288588 - 420 WP_134772167.1 hypothetical protein -
E3Z34_RS01345 288585..289070 - 486 WP_134772168.1 DUF2871 family protein -
E3Z34_RS01350 289363..290004 - 642 WP_134772169.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 285612..320447 34835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

Antitoxin MazE-like

(5-66)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11574.33 Da        Isoelectric Point: 6.4632

>T120812 WP_134772163.1 NZ_CP038213:c285938-285612 [Ornithinimicrobium flavum]
VRRGELWTVAGGVYASRPRPALIVQDDLFEGTASVTVAPLTTTLVDAPLLRVRVAADDLTGLQHDSQVMIDKVTTVRRQN
VGTHVGRLAPESLVEVERALMAFLGLAG

Download         Length: 327 bp

>T120812 NZ_CP038213:c285938-285612 [Ornithinimicrobium flavum]
GTGAGACGCGGTGAGCTGTGGACCGTCGCCGGGGGTGTCTACGCCTCCAGGCCAAGGCCCGCACTGATCGTGCAGGACGA
CCTCTTCGAGGGCACTGCCTCCGTGACCGTGGCGCCCCTGACGACGACGCTGGTCGATGCCCCTCTGCTTCGCGTACGCG
TCGCCGCCGATGATCTCACCGGTCTGCAGCACGACAGCCAGGTCATGATCGACAAGGTCACCACAGTTCGCCGCCAGAAC
GTCGGTACGCACGTTGGCCGCCTGGCGCCCGAAAGTCTCGTGGAGGTCGAACGCGCCCTGATGGCTTTCCTCGGCCTGGC
AGGGTAG

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 8071.96 Da        Isoelectric Point: 5.1425

>AT120812 WP_134772164.1 NZ_CP038213:c286141-285935 [Ornithinimicrobium flavum]
MTVKHRVSEYRRRMRARGLRPVQIWVPDVRSERFAQEAERQSALVARADEQSDDQEFVEAVTAPWDEE

Download         Length: 207 bp

>AT120812 NZ_CP038213:c286141-285935 [Ornithinimicrobium flavum]
ATGACGGTGAAGCATCGAGTCAGCGAGTACCGGCGCAGGATGCGCGCACGCGGCCTTCGACCCGTGCAGATCTGGGTGCC
GGACGTGCGTAGCGAGCGCTTTGCACAGGAGGCCGAACGTCAGTCGGCCCTGGTCGCGAGGGCGGACGAGCAGTCCGATG
ACCAGGAGTTCGTCGAAGCCGTCACCGCCCCCTGGGACGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References