Detailed information of TA system TA120810

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3967872..3968391
• Replicon: chromosome
• Accession: NZ_CP038207
• Organism: Pseudomonas sp. S150

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E3Z29_RS18180
• Protein ID: WP_098964185.1
• Coordinates: 3967872..3968153 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2R7MVA5
• Locus tag: E3Z29_RS18185
• Protein ID: WP_003225462.1
• Coordinates: 3968143..3968391 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3Z29_RS18150	3963161..3963925	-	765	WP_027612656.1	IclR family transcriptional regulator	-
E3Z29_RS18155	3964137..3964526	-	390	WP_007912330.1	RidA family protein	-
E3Z29_RS18160	3964557..3965354	-	798	WP_097087296.1	amino acid ABC transporter ATP-binding protein	-
E3Z29_RS18165	3965351..3966013	-	663	WP_134786515.1	amino acid ABC transporter permease	-
E3Z29_RS18170	3966023..3966685	-	663	WP_134786516.1	amino acid ABC transporter permease	-
E3Z29_RS18175	3966737..3967585	-	849	WP_098964184.1	transporter substrate-binding domain-containing protein	-
E3Z29_RS18180	3967872..3968153	-	282	WP_098964185.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E3Z29_RS18185	3968143..3968391	-	249	WP_003225462.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E3Z29_RS18190	3968668..3969096	+	429	WP_134786517.1	thioredoxin family protein	-
E3Z29_RS18195	3969263..3970822	-	1560	WP_134786518.1	TerC family protein	-
E3Z29_RS18200	3971238..3972884	-	1647	WP_134786519.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10911.69 Da
• Isoelectric Point: 10.6783

>T120810 WP_098964185.1 NZ_CP038207:c3968153-3967872 [Pseudomonas sp. S150]
MTYELEFSEKAWREWRKLDSALQDQFKKKLSTRLVNPHVPADRLRGLGNAYKIKLRSAGYRLVYRVKNEVLVVTVIAVGR
RERGEVYDKAACR

Nucleotide

• Length: 282 bp

>T120810 NZ_CP038207:c3968153-3967872 [Pseudomonas sp. S150]
ATGACCTATGAGCTGGAGTTTTCCGAGAAAGCCTGGAGGGAATGGAGAAAGCTTGATTCAGCACTTCAGGATCAGTTCAA
GAAAAAGCTCTCTACACGTCTGGTCAATCCTCACGTTCCTGCCGATCGACTCCGAGGGTTGGGAAACGCCTACAAAATCA
AGCTTCGCAGTGCTGGATACAGGCTGGTCTATCGCGTAAAGAACGAGGTTTTGGTTGTTACCGTGATTGCGGTAGGGAGA
AGAGAGCGGGGAGAGGTCTACGACAAAGCCGCTTGCCGATAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9005.38 Da
• Isoelectric Point: 4.5338

>AT120810 WP_003225462.1 NZ_CP038207:c3968391-3968143 [Pseudomonas sp. S150]
MTHVVLSNIVASISELKRNPMGTVAAGGGQSVAILNRNEPAFYCVPAKEYEAMMNRLEDLELIALCKERENDPTIKVSID
DL

Nucleotide

• Length: 249 bp

>AT120810 NZ_CP038207:c3968391-3968143 [Pseudomonas sp. S150]
ATGACTCACGTAGTTCTTTCCAATATCGTTGCGAGTATTTCTGAATTGAAAAGAAACCCCATGGGTACCGTGGCCGCCGG
TGGCGGCCAATCTGTTGCAATCCTCAATCGAAATGAGCCAGCGTTTTATTGTGTTCCCGCAAAGGAGTATGAGGCGATGA
TGAATCGCCTTGAGGATCTGGAACTGATCGCACTGTGCAAGGAGCGAGAAAACGATCCCACCATCAAGGTCTCTATAGAT
GACCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A2R7MVA5