Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1408547..1409076 Replicon chromosome
Accession NZ_CP038203
Organism Paracoccus pantotrophus strain DSM 11072

Toxin (Protein)


Gene name parE Uniprot ID A0A1I5JV80
Locus tag E3U24_RS07030 Protein ID WP_024845134.1
Coordinates 1408789..1409076 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1I5JVF8
Locus tag E3U24_RS07025 Protein ID WP_024845133.1
Coordinates 1408547..1408792 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3U24_RS06995 (E3U24_06935) 1403639..1403935 + 297 Protein_1369 transposase -
E3U24_RS07000 (E3U24_06940) 1404012..1404566 - 555 WP_114669602.1 helix-turn-helix transcriptional regulator -
E3U24_RS07005 (E3U24_06945) 1404685..1404927 + 243 WP_240540236.1 hypothetical protein -
E3U24_RS07010 (E3U24_06950) 1405127..1406227 + 1101 WP_114669600.1 tyrosine-type recombinase/integrase -
E3U24_RS07015 (E3U24_06955) 1406256..1407013 + 758 WP_089852160.1 IS5 family transposase -
E3U24_RS07020 (E3U24_06960) 1407081..1408442 + 1362 WP_028710598.1 plasmid recombination protein -
E3U24_RS07025 (E3U24_06965) 1408547..1408792 + 246 WP_024845133.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
E3U24_RS07030 (E3U24_06970) 1408789..1409076 + 288 WP_024845134.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E3U24_RS07035 (E3U24_06975) 1409095..1409667 + 573 WP_147278009.1 hypothetical protein -
E3U24_RS07040 (E3U24_06980) 1409891..1411063 - 1173 WP_036747930.1 ATP-binding protein -
E3U24_RS07045 (E3U24_06985) 1411207..1411545 - 339 WP_028710997.1 metalloregulator ArsR/SmtB family transcription factor -
E3U24_RS07050 (E3U24_06990) 1411588..1412109 + 522 WP_051419865.1 DUF6428 family protein -
E3U24_RS07055 (E3U24_06995) 1412115..1412651 + 537 WP_181817367.1 arsenate reductase ArsC -
E3U24_RS07060 (E3U24_07000) 1412662..1413093 + 432 WP_028710994.1 arsenate reductase (glutaredoxin) -
E3U24_RS07065 (E3U24_07005) 1413109..1413837 + 729 Protein_1383 ACR3 family arsenite efflux transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1382656..1415982 33326


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-90)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10744.14 Da        Isoelectric Point: 6.0719

>T120804 WP_024845134.1 NZ_CP038203:1408789-1409076 [Paracoccus pantotrophus]
MKALAFTVAATVDLEDIWDYTEGEWGLAQARRYVQELRDTCHALASGERRGRSVDVRPGYLKCLSGSHVIFFRDLGDTLE
IVRILHGAQDAERHL

Download         Length: 288 bp

>T120804 NZ_CP038203:1408789-1409076 [Paracoccus pantotrophus]
ATGAAGGCGTTGGCCTTCACCGTCGCGGCAACGGTCGATCTGGAGGATATCTGGGATTATACGGAAGGCGAATGGGGCCT
CGCGCAAGCCCGGCGCTATGTGCAGGAGCTGCGCGACACCTGCCATGCGCTGGCATCGGGTGAAAGGCGCGGCAGGTCGG
TTGACGTTCGGCCTGGCTATCTGAAGTGCCTGAGCGGATCGCATGTCATCTTCTTCCGGGATCTGGGCGATACGCTGGAA
ATCGTCCGCATCCTGCACGGCGCGCAGGACGCCGAGCGGCATTTGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8709.78 Da        Isoelectric Point: 6.4652

>AT120804 WP_024845133.1 NZ_CP038203:1408547-1408792 [Paracoccus pantotrophus]
MSRNTSVSLGDHFVSFIDAQVKGGRYGSASDVVRAGLRLLEEHETKVKALEAALIAGEESGRAEGFDLDQFIARKMAGRN
A

Download         Length: 246 bp

>AT120804 NZ_CP038203:1408547-1408792 [Paracoccus pantotrophus]
ATGTCCCGCAACACTTCGGTTTCGCTCGGCGATCACTTCGTCAGCTTCATCGACGCGCAGGTGAAGGGCGGCCGCTATGG
CTCGGCCAGCGACGTGGTGCGGGCAGGGCTGCGGCTTCTGGAGGAGCACGAGACCAAGGTAAAGGCGTTGGAAGCCGCCC
TGATCGCCGGAGAGGAATCCGGCCGGGCGGAAGGCTTCGACCTCGATCAATTCATTGCCCGCAAGATGGCCGGTCGCAAC
GCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I5JV80

Antitoxin

Source ID Structure
AlphaFold DB A0A1I5JVF8

References